Results: 10

Carcinogénesis Oral y Epigenética

A pesar de que los procesos epigenéticos son estudiados ampliamente de forma general, no se habían relacionado, hasta ahora, a las alteraciones genéticas más tradicionales asociadas en la etiopatogenia del cáncer oral. La visión de carcinogénesis tradicional y la de la epigenética convergen en la...

Non-coding RNAs and chromatin: key epigenetic factors from spermatogenesis to transgenerational inheritance

Biol. Res; 54 (), 2021
Cellular fate and gene expression patterns are modulated by different epigenetic factors including non-coding RNAs (ncRNAs) and chromatin organization. Both factors are dynamic throughout male germ cell differentiation on the seminiferous tubule, despite the transcriptional inactivation in the last stage...

Bases neurobiológicas del autismo y modelos celulares para su estudio experimental
Neurobiological bases of autism and cellular models for its experimental study

Medicina (B.Aires); 79 (1,supl.1), 2019
Los trastornos del espectro autista (TEA) son una alteración funcional de la corteza cerebral, que presenta anomalías estructurales del neurodesarrollo que afectan fundamentalmente a la función sináptica y el patrón de conexiones dentro y entre columnas corticales. Desde su aspecto etiológico, el T...

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Braz. j. med. biol. res; 51 (12), 2018
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart fail...

An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation

Mem. Inst. Oswaldo Cruz; 113 (6), 2018
Toxoplasma gondii uses epigenetic mechanisms to regulate both endogenous and host cell gene expression. To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins. Step 1 employs PredictNLS and NucPred to identify genes ...

Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies

J. pediatr. (Rio J.); 93 (6), 2017
Abstract Objective: To discuss the recent literature on paternal obesity, focusing on the possible mechanisms of transmission of the phenotypes from the father to the children. Sources: A non-systematic review in the PubMed database found few publications in which paternal obesity was implicated in the...

Epigenética del síndrome de ovario poliquístico

Rev. méd. Chile; 145 (7), 2017
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a...

Conceptos generales de epigenética: proyecciones en pediatría

Rev. chil. pediatr; 87 (1), 2016
La asociación entre factores ambientales presentes durante el desarrollo embrionario/fetal y enfermedades que puedan presentarse durante la vida representa un campo de creciente interés. En este contexto la evidencia actual apoya fuertemente que alteraciones en el crecimiento intrauterino y durante los...

Lipídios estruturados obtidos por interesterificação da tributirina com óleo de linhaça e seu potencial quimiopreventivo durante a fase de promoção inicial da hepatocarcinogênese experimental em ratos

A combinação de agentes quimiopreventivos com diferentes mecanismos de ação tem sido considerada uma estratégia promissora para a prevenção do câncer. Dentre os diversos compostos bioativos em alimentos, destacam-se a tributirina, um pró-fármaco do ácido butírico presente em laticínios e pro...