LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The morphology of paca (Cuniculus paca) testis with high dose of letrozole an aromatase inhibitor

Simões, Luciana Senna; Sasahara, Taís Harumi de Castro; Favaron, Phelipe Oliveira; Leal, Leonardo Martins; Oliveira, Fabrício Singaretti de; Fratini, Paula; Berger, Trish; Machado, Marcia Rita Fernandes; Miglino, Maria Angélica.

Int. j. morphol; 38 (6), 2020

SUMMARY: The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spermatogenesis. Morphological changes were observed in seminiferous epithelium with ...

Cuniculidae, Testículo/efectos de los fármacos, Letrozol/administración & dosificación, Inhibidores de la Aromatasa/administración & dosificación, Espermatogénesis/efectos de los fármacos, Microscopía Electrónica de Transmisión, Inmunohistoquímica, Orquiectomía, Células Germinativas/efectos de los fármacos, Epitelio Seminífero/efectos de los fármacos

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Toxicological effects of bioactive peptide fractions obtained from Bothrops jararaca snake venom on the structure and function of mouse seminiferous epithelium

Alberto-Silva, Carlos; Franzin, Celline Sampaio; Gilio, Joyce Meire; Bonfim, Rodrigo Simão; Querobino, Samyr Machado.

J. venom. anim. toxins incl. trop. dis; 26 (), 2020

Pathogenesis of Bothrops envenomations is complex and despite numerous studies on the effects of this snake venom on various biological systems, relatively little is known about such effects on the male reproductive system. In the present study, the toxicological outcomes of the low molecular weight frac...

Venenos de Serpiente, Bothrops, Péptidos, Productos Biológicos, Epitelio Seminífero, Espermatogénesis

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Angiotensin-converting enzyme inhibitors of Bothrops jararaca snake venom affect the structure of mice seminiferous epithelium

Alberto-Silva, Carlos; Gilio, Joyce M; Portaro, Fernanda C. V; Querobino, Samyr M; Camargo, Antonio C. M.

J. venom. anim. toxins incl. trop. dis; 21 (), 2015

Background Considering the similarity between the testis-specific isoform of angiotensin-converting enzyme and the C-terminal catalytic domain of somatic ACE as well as the structural and functional variability of its natural inhibitors, known as bradykinin-potentiating peptides (BPPs), the effects of di...

Venenos de Serpiente, Inhibidores de la Enzima Convertidora de Angiotensina, Epitelio Seminífero, Bothrops, Isoformas de Proteínas

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Human testis-expressed sequence 101 is limitedly distributed in germinal epithelium of testis and disappears in seminoma

Shen, Cong-Cong; Kang, Yu-Huan; Yu, Lin; Cui, Dan-Dan; He, Yi; Yang, Jin-Liang; Gou, Lan-Tu.

Biol. Res; 47 (), 2014

BACKGROUND: Testis-expressed sequence 101 (TEX101) was found to be highly expressed in testis and involved in acrosome reaction in previous studies. Recently, the metastasis suppressor function of TEX101 in cancer was disclosed, but the comprehensive investigation of its expression has rarely been report...

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A bradykinin-potentiating peptide (BPP-10c) from Bothrops jararaca induces changes in seminiferous tubules

Gilio, Joyce M; Portaro, Fernanda C. V; Borella, Maria I; Lameu, Claudiana; Camargo, Antonio C. M; Alberto-Silva, Carlos.

J. venom. anim. toxins incl. trop. dis; 19 (), 2013

Background The testis-specific isoform of angiotensin-converting enzyme (tACE) is exclusively expressed in germ cells during spermatogenesis. Although the exact role of tACE in male fertility is unknown, it clearly plays a critical function in spermatogenesis. The dipeptidase domain of tACE is identical ...

Bothrops/anatomía & histología, Péptidos, Túbulos Seminíferos, Venenos de Serpiente, Epitelio Seminífero, Bradiquinina

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