ABSTRACT Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been report...
Introducción: La esclerosis sistémica es una enfermedad autoinmune del tejido conectivo donde ocurre inicialmente la vasculopatía y persiste durante toda la enfermedad. El índice de actividad revela un periodo crítico de la enfermedad. Objetivo: Evaluar la evolución clínica del índice de activ...
Abstract Background: Systemic sclerosis (SSc) Is a clinically complex and challenging disease, that leads to skin fibrosis. Its most frequent complication is interstitial lung disease (ILD), which leads to a worse prognosis. In this situation, cyclophosphamide is considered the gold standard for its tre...
esclerose sistêmica é uma enfermidade autoimune, causadora de danos vasculares e fibroses. É dentre as doenças de sistema conjuntivo, bem conhecida, devido à alta mortalidade, principalmente pelas causas pulmonares e cardíacas. Para a avaliação do tecido cutâneo de portadores de esclerose sistê...
Abstract Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and mortality. Although cyclophosphamide is effective for severe and refractory cases, there is demand for new treatments. The biological treatment with B-cell depletion with rituximab (RTX) has demonstrated efficacy ...
Trabajo realizado en el Hospital Arzobispo Loayza (Lima) entre 1985-1987, dentro de un protocolo de estudio a doble ciego de 5 fluorouracilo en el tratamiento de esclerosis sistémica progresiva (ESP). El objetivo fue evaluar en forma prospectiva las alteraciones inducidas por ESP en la motilidad esofág...
