LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Disability and progression in Afro-descendant patients with multiple sclerosis

ABSTRACT Multiple sclerosis (MS) prevalence is higher in Caucasian (CA) populations, narrowing the analysis of the impact of Afro-descendant (AD) populations in disease outcomes. Even so, recent studies observed that AD patients have a more severe course. The main objective of this study is to confirm an...

The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population

Werneck, Lineu Cesar; Lorenzoni, Paulo José; Arndt, Raquel Cristina; Kay, Cláudia Suemi Kamoi; Scola, Rosana Herminia.

Arq. neuropsiquiatr; 74 (8), 2016

ABSTRACT Objective To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil. Methods We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles wit...

Alelos, Brasil, Estudios de Casos y Controles, Población Blanca, Frecuencia de los Genes, Predisposición Genética a la Enfermedad/genética, Genotipo, Antígenos de Histocompatibilidad Clase I/genética, Antígenos de Histocompatibilidad Clase II/genética, Fenómenos Inmunogenéticos, Esclerosis Múltiple/etnología, Esclerosis Múltiple/genética

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