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Ultrastructural morphological alterations during hyperoxia exposure in relation to glutathione peroxidase activity and free radicals productions in the mitochondria of the cortical brain

Bin-Jaliah, Ismaeel; Haffor, Al-Said.
Int. j. morphol; 36 (4), 2018
Exposure to normobaric hyperoxia (NH) is known to increase the production of reactive oxygen species (ROS) by mitochondria. The present study was designed to examine mitochondrial ultrastructure morphological changes in the cortical brainin relation to glutathione peroxidase (GPX) activity and free radic...
Hiperoxia/patología, Corteza Cerebral/patología, Corteza Cerebral/ultraestructura, Glutatión Peroxidasa/metabolismo, Especies Reactivas de Oxígeno, Especies de Nitrógeno Reactivo, Mitocondrias/patología, Corteza Cerebral/enzimología, Análisis de Varianza, Mitocondrias/ultraestructura, Ratas Wistar
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Action of vitamin e on experimental severe acute liver failure

Miguel, Fabiano Moraes; Schemitt, Elizângela Gonçalves; Colares, Josieli Raskopf; Hartmann, Renata Minuzzo; Morgan-Martins, Maria Isabel; Marroni, Norma Possa.
Arq. gastroenterol; 54 (2), 2017
ABSTRACT BACKGROUND Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in...
Alanina Transaminasa/sangre, Fosfatasa Alcalina/sangre, Antioxidantes/uso terapéutico, Aspartato Aminotransferasas/sangre, Modelos Animales de Enfermedad, Fallo Hepático Agudo/enzimología, Fallo Hepático Agudo/patología, Fallo Hepático Agudo/prevención & control, Ratas Wistar, Especies de Nitrógeno Reactivo/metabolismo, Especies Reactivas de Oxígeno/metabolismo, Índice de Severidad de la Enfermedad, Vitamina E/uso terapéutico
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