The neuroprotective effect of flower and fruit parts of Capparis ovata Desf. var. palaestina Zoh. plant was investigated in H2O2-induced cytotoxicity in SH-SY5Y cells. The cells were treated with H2O2 alone or pretreated with flower (COMFL) and fruit extract (COMFR) of C. ovatavar. palaesti...
Capparis/química,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Fármacos Neuroprotectores/farmacología,
Fármacos Neuroprotectores/química,
Peróxido de Hidrógeno/toxicidad,
Cromatografía Líquida con Espectrometría de Masas,
Espectrometría de Masas en Tándem,
Neuroblastoma,
Estrés Oxidativo/efectos de los fármacos,
Muerte Celular/efectos de los fármacos,
Ácidos Cafeicos/análisis,
Flavonoides/análisis,
Fenoles/análisis,
Ácidos Grasos Monoinsaturados/análisis,
Enfermedades Neurodegenerativas/prevención & control
Cancer is an important disease that causing to deaths in the world. Cervical cancer is one of the most common among women and must be treated quickly to prevent cell proliferation. Natural products have been used for cancer treatment due to their antiproliferative and apoptosis induction pro...
Inula/química,
Apoptosis/efectos de los fármacos,
Antineoplásicos Fitogénicos/uso terapéutico,
Neoplasias del Cuello Uterino/tratamiento farmacológico,
Plantas Medicinales,
Antineoplásicos Fitogénicos/farmacología,
Antineoplásicos Fitogénicos/química,
Extractos Vegetales/uso terapéutico,
Extractos Vegetales/farmacología,
Extractos Vegetales/química,
Proliferación Celular/efectos de los fármacos,
Especies Reactivas de Oxígeno,
Espectrometría de Masas en Tándem,
Células HeLa/efectos de los fármacos,
Interleucina-6/análisis,
Interleucina-8/análisis,
Metanol,
Antioxidantes,
Flavonoides/análisis,
Cromatografía Líquida de Alta Presión
Abstract Species of the genus Cordia have shown biological activities, such as anti-inflammatory, analgesic, antioxidant, antiviral, and antifungal activities. The species Cordia glabrata (MART) A.DC. Has no information concerning its phytochemical profile and possible biological activities. Thus, this s...
Costa, S C C;
Damasceno, P K F;
Lima, R G G;
Botura, M B;
Branco, C R C;
Silva, T R S;
Oliveira, A P;
Guimarães, A L;
Almeida, J R G S;
Branco, A.
Abstract The antioxidant, photoprotective and antinociceptive Marcetia macrophylla active extract was investigated as an active ingredient in a sunscreen cream formulation. Thus, the M. macrophylla extract showed IC50 of 3.43 mg/ml of the antioxidant (DPPH∙ scavenging test) and Sun Protection Facto...
Abstract In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volun...
Abstract Dasatinib, a potent oral multi-targeted kinase inhibitor against Src and Bcr-Abl, can decrease inflammatory response in sepsis. A simple and cost-effective method for determination of an effective dose dasatinib was established. This method was validated in human plasma, with the aim of reducing...
Introduction: Imatinib mesylate is currently the first-line oral treatment for all stages of chronic myeloid leukemia (CML) and is also used in some cases of gastrointestinal stromal tumor (GIST) and acute lymphoblastic leukemia (ALL). Objective: Investigate the bioavailability of two products containing...
RESUMEN: Determinar las variaciones diurnas de las concentraciones de cortisol salival (CORTs) en adultos jóvenes sanos. Estudio descriptivo de corte transversal. Un total de 50 estudiantes universitarios, sin antecedentes de trastornos físicos o psiquiátricos, recogieron muestras de saliva completa n...
Saliva/química,
Cortisona/análisis,
Cortisona/metabolismo,
Ritmo Circadiano/fisiología,
Hidrocortisona/análisis,
Hidrocortisona/metabolismo,
Cromatografía Liquida,
Espectrometría de Masas en Tándem,
Estudios Transversales,
Epidemiología Descriptiva,
Demografía
Solanum nudum Dunal (Solanaceae) is most commonly known andused by the population of the colombian Pacific coast as an antimalarial treatment. This article study into optimization and quantitative analysis of compounds steroidal over time of development of this species when grown in vitro and wild. A n...
