A doença de Chagas, considerada doença extremamente negligenciada, acomete mais de 6 milhões de pessoas ao redor do mundo e mais de 75 milhões de pessoas vivem sob risco da doença. Considerada endêmica em 21 países da América Latina. No Brasil, grassa, sobretudo, na região Norte, especialmente, ...
Dendrímeros/análisis,
Receptor de Manosa/antagonistas & inhibidores,
Macrófagos/clasificación,
Enfermedad de Chagas/patología,
Biofarmacia/clasificación,
d0193590,
ddcs0324490,
Espectroscopía de Protones por Resonancia Magnética/métodos,
Espectroscopía de Resonancia Magnética con Carbono-13/métodos,
d0083620,
ddcs0514400,
Preparaciones Farmacéuticas/administración & dosificación
Abstract Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility and bioavailability of these compounds. A novel synthetic OxD was used, and its inclusion complexes were based on 2-hydro...
Abstract A phytochemical study of Tecoma genus (Bignoniaceae) was accomplished by antitumor activity of ethanolic extracts. Species of this genus are composed of small shrubs often used as ornamental plants. The Tecoma stans species is used in folk medicine for different purposes. Recent work shows in vi...
A inibição de alvos específicos como metaloproteinase de matriz (MMP) e histona desacetilase (HDAC) é amplamente estudada para impedir o progresso do câncer. Foi estabelecido que a inibição concomitante de MMP e HDAC é eficaz no combate de tumores sólidos e hematológicos. Ambos os alvos possuem...
Apesar da grande relevância médica e social, e por serem responsáveis por grande parte das mortes em países subdesenvolvidos e em desenvolvimento as doenças negligenciadas (DN), ainda, não apresentam terapêutica eficaz. Dentre as diversas DN, doenças como a doença de Chagas, a Leishmaniose visce...
Preparaciones Farmacéuticas/administración & dosificación,
Enfermedades Desatendidas/complicaciones,
Espectroscopía de Protones por Resonancia Magnética/métodos,
Espectroscopía de Resonancia Magnética con Carbono-13,
Antineoplásicos/análisis,
Antiparasitarios/efectos adversos,
Cromatografía Líquida de Alta Presión/métodos,
Estrategias de Salud,
Países en Desarrollo/clasificación,
Preparaciones Farmacéuticas/análisis,
Chalconas/efectos adversos
Iqbal, Javed;
Rehman, Aziz-ur-;
Abbasi, Muhammad Athar;
Siddiqui, Sabahat Zahra;
Rasool, Shahid;
Ashraf, Muhammad;
Iqbal, Ambar;
Hamid, Sujhla;
Chohan, Tahir Ali;
Khalid, Hira;
Laulloo, Sabina Jhaumeer;
Shah, Syed Adnan Ali.
We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction of the...
Simulación por Computador/clasificación,
Sulfonamidas/efectos adversos,
Aminoácidos/antagonistas & inhibidores,
Análisis de Datos,
Concentración 50 Inhibidora,
Bacillus subtilis/clasificación,
Espectroscopía de Protones por Resonancia Magnética/métodos,
Inhibidores de la Colinesterasa/farmacología,
Preparaciones Farmacéuticas/administración & dosificación,
Salmonella typhi/clasificación,
Albúmina Sérica Bovina,
Ureasa,
Tiourea
Docetaxel-loaded acetic acid conjugated Cordyceps sinensis polysaccharide (DTX-AA-CSP) nanoparticles were prepared through dialysis and their release rates in vitro, particle sizes, zeta potentials, drug loading capacities, and encapsulation efficiencies were characterized for the synthesis of AA-modifie...
Weaning results in intestinal dysfunction, mucosal atrophy, transient anorexia, and intestinal barrier defects. In this study, the effect of prodigiosin (PG) on the intestinal inflammation of weaned rats was investigated by using 1H-NMR spectroscopy and biochemistry indexes to regulate the intestinal met...
ABSTRACT Objective: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 ...
Carcinoma/diagnóstico por imagen,
Colina/análisis,
Creatina/análisis,
Estudios Prospectivos,
Espectroscopía de Protones por Resonancia Magnética/métodos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Sensibilidad y Especificidad,
Estadísticas no Paramétricas,
Neoplasias de la Tiroides/diagnóstico por imagen,
Nódulo Tiroideo/diagnóstico por imagen
ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complet...
