Results: 2

Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients

JOAQUIM, HELENA P. G; COSTA, ALANA C; FORLENZA, ORESTES V; GATTAZ, WAGNER F; TALIB, LEDA L.

Arch. Clin. Psychiatry (Impr.); 46 (5), 2019

Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...

Poliaminas/sangre, Disfunción Cognitiva/fisiopatología, Enfermedad de Alzheimer/fisiopatología, Cromatografía Liquida/métodos, Espectrometría de Masas en Tándem/métodos, Biomarcadores/sangre, Espermina/sangre, Metabolómica/métodos, Poliaminas/metabolismo, Enfermedad de Alzheimer/diagnóstico, Disfunción Cognitiva/diagnóstico, Espermidina/sangre, Ornitina/sangre, Putrescina/sangre

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A useful procedure for detection of polyamines in biological samples as a potential diagnostic tool in cancer diagnosis

Balcerzak, W; Pokajewicz, K; Wieczorek, PP.

Appl. cancer res; 37 (), 2017

Background: Polyamines present in human body are frequently considered as markers of occurrence of cancer. Therefore, the availability of simple and efficient method for determination of their level in body liquids and tissues is of some interest. Methods: Supported liquid membrane technology coupled wit...

Espermina, Espermidina, Cadaverina, Putrescina, Poliaminas/síntesis química, Neoplasias/diagnóstico, Biomarcadores de Tumor/clasificación

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