Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients
Arch. Clin. Psychiatry (Impr.); 46 (5), 2019
Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...
Poliaminas/sangre, Disfunción Cognitiva/fisiopatología, Enfermedad de Alzheimer/fisiopatología, Cromatografía Liquida/métodos, Espectrometría de Masas en Tándem/métodos, Biomarcadores/sangre, Espermina/sangre, Metabolómica/métodos, Poliaminas/metabolismo, Enfermedad de Alzheimer/diagnóstico, Disfunción Cognitiva/diagnóstico, Espermidina/sangre, Ornitina/sangre, Putrescina/sangre