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In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes

Hassan, Ehssan Ahmed; Abdel-Rahman, Mohamed Ahmed; Ibrahim, Mohamed Moussa; Soliman, Maha Farid Mohamed.
Rev. Soc. Bras. Med. Trop; 49 (6), 2016
Abstract INTRODUCTION: We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. METHODS: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual...
Cricetinae, Relación Dosis-Respuesta a Droga, Egipto, Dosificación Letal Mediana, Microscopía Electrónica de Rastreo, Schistosoma mansoni/efectos de los fármacos, Schistosoma mansoni/ultraestructura, Esquistosomicidas/aislamiento & purificación, Esquistosomicidas/farmacología, Factores de Tiempo, Venenos de Víboras/farmacología
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Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel

Brindley, Paul J; Sher, Alan.
Mem. Inst. Oswaldo Cruz; 82 (supl.4), 1987
This paper reports recent observations from our laboratory dealing with the anti-schistosome drugs hycanthone (HC) and praziquantel (PZQ). In particular, we discuss a laboratory model of drug resistance to HC in Schistosoma mansoni and show that drug sensitive and resistant lines of the parasite can be d...
Esquistosomicidas/uso terapéutico, Esquistosomicidas/provisión & distribución, Esquistosomicidas/farmacología
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