LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Differential expression profiles of miRNAs and their putative targets in Schistosoma mansoni during its life cycle

Abreu, Fabiano CP; Mota, Ester Alves; Pereira, Roberta V; Oliveira, Victor F; Costa, Marcela P; Gomes, Matheus de S; Jannotti-Passos, Liana K; Borges, William C; Guerra-Sá, Renata.

Mem. Inst. Oswaldo Cruz; 116 (), 2021

BACKGROUND Schistosomiasis is a disease caused by Schistosoma. Due to its complex life cycle, evolutionary position and sexual dimorphism, schistosomes have several mechanisms of gene regulation. MicroRNAs (miRNAs) are short endogenous RNAs that regulate gene expression at the post-transcriptional level...

Perfilación de la Expresión Génica, Regulación de la Expresión Génica/genética, Estadios del Ciclo de Vida/genética, MicroARNs/genética, Schistosoma mansoni/genética, Transducción de Señal

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Trypanosoma cruzi transcriptome during axenic epimastigote growth curve

BACKGROUND Trypanosoma cruzi is an important protozoan parasite and the causative agent of Chagas disease. A critical step in understanding T. cruzi biology is the study of cellular and molecular features exhibited during its growth curve. OBJECTIVES We aimed to acquire a global view of the gene expres...