LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

Wang, Guangchuan; Li, Zhen; Li, Xiao; Zhang, Chunqing; Peng, Lipan.

Biol. Res; 52 (), 2019

BACKGROUND: Recent studies have confirmed that RASAL1 has an antitumor effect in many cancers, but its functional role and the molecular mechanism underlying in colon cancer has not been investigated. RESULTS: We collected human colon cancer tissues and adjacent non-tumor tissues, human colon cancer cell...

Proliferación Celular/fisiología, Neoplasias del Colon/patología, Proteínas Activadoras de GTPasa/metabolismo, Receptores X del Hígado/metabolismo, Estearoil-CoA Desaturasa/metabolismo, Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo, Proteínas Activadoras de GTPasa/genética, Receptores X del Hígado/genética, Estearoil-CoA Desaturasa/genética, Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética, Línea Celular Tumoral, Regulación hacia Abajo

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Diet high in alpha-linolenic acid up-regulate PPAR-gamma gene expression in the liver of goats

Background There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-lin...