LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Eficácia da aplicação endoscópica tópica de mitomicina C em estenoses esofágicas cáusticas na população pediátrica: uma revisão sistemática e meta-análise de ensaios clínicos randomizados

ABSTRACT BACKGROUND: Caustic ingestion and development of esophageal strictures are recognized major public health problems in childhood. Different therapeutic methods have been proposed in the management of such strictures. OBJECTIVE: To evaluate efficacy and risk of endoscopic topical application o...

Cordycepin prevents the esophageal stricture formation in the alkali-burn rat model by exerting anti-inflammatory and antifibrotic effects

Ercan, Gulcin; Altinel, Yuksel; Karagulle, Onur Olgac; Yiğitbaş, Hakan; Hacım, Nadir Adnan; Meriç, Serhat; Buğdaycı, Nihat; Tartar, Rumeysa Ilbar; Biltekin, Burcu; Yavuz, Erkan; Gulcicek, Osman Bilgin; Solmaz, Ali; Çelik, Atilla.

Acta cir. bras; 36 (3), 2021

ABSTRACT Purpose To investigate the efficacy of cordycepin, an adenosine analogue, on prevention of esophageal damage and stricture formation due to esophageal caustic burns in rat model comparing with prednisolone. Methods Caustic esophageal burn was introduced by 37.5% of NaOH to distal esophagus. Th...

Álcalis/uso terapéutico, Antiinflamatorios/uso terapéutico, Quemaduras Químicas/tratamiento farmacológico, Cáusticos/toxicidad, Desoxiadenosinas, Estenosis Esofágica/inducido químicamente, Estenosis Esofágica/tratamiento farmacológico, Estenosis Esofágica/prevención & control, Ratas Wistar, Factor A de Crecimiento Endotelial Vascular/uso terapéutico, Cáusticos/uso terapéutico

Fulltext