Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially in vitro as a neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and neuron-inflammatory response via microglial activ...
Tasca, Silvio;
Campos, Cristina;
Lacerda, Denise;
Ortiz, Vanessa D;
Turck, Patrick;
Bianchi, Sara E;
Castro, Alexandre L. de;
Belló-Klein, Adriane;
Bassani, Valquiria;
Araújo, Alex Sander da Rosa.
Resumo Fundamento O pterostilbeno (PS), um composto polifenólico natural e antioxidante, surge como uma intervenção promissora para minimizar danos do infarto agudo do miocárdio (IAM). Objetivo Este estudo teve como objetivo avaliar o desempenho do PS na promoção da homeostase redox nos pulmõe...
Menezes-Rodrigues, Francisco Sandro;
Errante, Paolo Ruggero;
Araújo, Erisvaldo Amarante;
Fernandes, Mariana Pontes Pacheco;
Silva, Michele Mendes da;
Pires-Oliveira, Marcelo;
Scorza, Carla Alessandra;
Scorza, Fúlvio Alexandre;
Taha, Murched Omar;
Caricati-Neto, Afonso.
ABSTRACT Purpose To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as grape juice and red wine, in animal model of cardiac ischemia and reperfusion. Methods Male Wistar rats orally pretreated for 21-days with resveratrol and grape products were anesthetized and...
Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed ...
Apoptosis/efectos de los fármacos,
Hipoxia de la Célula/efectos de los fármacos,
Línea Celular,
Proliferación Celular/efectos de los fármacos,
Citoprotección,
Glucósidos/farmacología,
Miocitos Cardíacos/efectos de los fármacos,
Miocitos Cardíacos/metabolismo,
Miocitos Cardíacos/patología,
ARN Largo no Codificante/efectos de los fármacos,
Transducción de Señal,
Estilbenos/farmacología,
Regulación hacia Arriba/efectos de los fármacos
Resveratrol in cell culture media increases osteoblastic markers. Also results from previous studies provide evidence for resveratrol positive effects on bone healing and bone production. In this preclinical study we investigated bone healing in rats by resveratrol systemic application. 30 Wistar male ra...
Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wo...
Apoptosis/efectos de los fármacos,
Western Blotting,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/patología,
Línea Celular Tumoral,
Movimiento Celular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos,
Medicamentos Herbarios Chinos,
Citometría de Flujo,
Glucósidos/farmacología,
Neoplasias Hepáticas Experimentales/tratamiento farmacológico,
Neoplasias Hepáticas Experimentales/patología,
Ratones Endogámicos BALB C,
Ratones Desnudos,
Invasividad Neoplásica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estilbenos/farmacología
Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline soluti...
Antioxidantes/farmacología,
Carotenoides/farmacología,
Hepatectomía/métodos,
Hígado/efectos de los fármacos,
Hígado/cirugía,
Estilbenos/farmacología,
Alanina Transaminasa/sangre,
Apoptosis/efectos de los fármacos,
Aspartato Aminotransferasas/sangre,
Hígado/enzimología,
Hígado/patología,
Regeneración Hepática/efectos de los fármacos,
Índice Mitótico,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Background: Despite knowing that resveratrol has effects on blood vessels, blood pressure and that phytostrogens can also improve the endothelium-dependent relaxation/vasodilation, there are no reports of reveratrol's direct effect on the endothelial function and blood pressure of animals with ...
Antioxidantes/farmacología,
Antioxidantes/uso terapéutico,
Presión Sanguínea/efectos de los fármacos,
Presión Sanguínea/fisiología,
Endotelio Vascular/efectos de los fármacos,
Endotelio Vascular/fisiología,
Estrógenos/deficiencia,
Hipertensión/tratamiento farmacológico,
Hipertensión/metabolismo,
Nitratos/sangre,
Óxido Nítrico/sangre,
Ovariectomía,
Ratas Wistar,
Valores de Referencia,
Reproducibilidad de los Resultados,
Resveratrol,
Estilbenos/farmacología,
Estilbenos/uso terapéutico,
Factores de Tiempo,
Resultado del Tratamiento
Introduction: Grape is one of the most important fruit crops across the world and
can be consumed in different ways. There has been a growing interest in the role
of antioxidants such as resveratrol, which can be found in grape skin, in oral and
dental tissues. Thus, the objective of this study was to an...
BACKGROUND: Melanoma took top position among the lethal cancers and, despite there have been some great attempts made to increase the natural life of patients with metastatic disease, long-lasting and complete remissions are few. Piceatannol, owns the similar function as resveratrol, has been defined as ...
Anticarcinógenos/farmacología,
Apoptosis/efectos de los fármacos,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Melanoma/tratamiento farmacológico,
MicroARNs/efectos de los fármacos,
Estilbenos/farmacología,
Melanoma/metabolismo,
Melanoma/patología,
MicroARNs/metabolismo,
Línea Celular Tumoral,
Supervivencia Celular,
Regulación hacia Arriba
