Macrophage migration inhibitory factor antagonist (p425) ameliorates kidney histopathological and functional changes in diabetic rats
J. bras. nefrol; 41 (3), 2019
Abstract Introduction: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. Methods: Eight...
Albuminuria/tratamiento farmacológico, Glucemia, Creatinina/sangre, Creatinina/orina, Diabetes Mellitus Experimental/sangre, Diabetes Mellitus Experimental/inducido químicamente, Diabetes Mellitus Experimental/patología, Diabetes Mellitus Experimental/orina, Nefropatías Diabéticas/sangre, Nefropatías Diabéticas/terapia, Nefropatías Diabéticas/patología, Nefropatías Diabéticas/orina, Modelos Animales de Enfermedad, Glicosaminoglicanos/orina, Oxidorreductasas Intramoleculares/antagonistas & inhibidores, Riñón/patología, Activación de Macrófagos, Factores Inhibidores de la Migración de Macrófagos/antagonistas & inhibidores, Sustancias Protectoras/farmacología, Sustancias Protectoras/uso terapéutico, Ratas Wistar, Estreptozocina/farmacología