Abstract The aim of this study was to evaluate tumor necrosis factor alpha (TNF-α), interleukin (IL)- 17A/F levels in the serum of ankylosing spondylitis (AS) patients after anti-TNF therapy, in order to understand how these cytokines are involved in this therapeutic response. Forty-four AS patients wer...
Abstract Abscisic acid (ABA) is a plant hormone that plays several roles in plant development. The de novo synthesis and the reversible inactivation of ABA have been largely described in the literature; however, the degradation of ABA, promoted by the enzymes Abscisic Acid 8'-Hydroxylase, encoded by the ...
Abstract Background: Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different ...
Alopecia Areata/genética,
Antígeno CTLA-4/genética,
Estudios de Casos y Controles,
Frecuencia de los Genes,
Estudios de Asociación Genética,
Predisposición Genética a la Enfermedad,
Variación Genética/genética,
Técnicas de Genotipaje,
México,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple,
Factores de Riesgo
Abstract Background: Cytochrome P450 2J2 is mostly expressed in extrahepatic tissues; it metabolizes arachidonic acid to epoxyeicosatrienoic acids, with various cardio protective and anti-inflammatory effects. CYP2J2 polymorphism has been identified as a risk factor for cardiovascular diseases, but its ...
Edad de Inicio,
Enfermedades Cardiovasculares/genética,
Estudios de Casos y Controles,
Sistema Enzimático del Citocromo P-450/genética,
Frecuencia de los Genes,
Estudios de Asociación Genética,
Genotipo,
Persona de Mediana Edad,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Psoriasis/genética,
Factores de Riesgo,
Estadísticas no Paramétricas,
Turquía
Abstract Genetic and epigenetic changes have been associated with periodontitis in various genes; however, little is known about genes involved in epigenetic mechanisms and in oxidative stress. Objective: This study aims to investigate the association of polymorphisms C677T in MTHFR (rs1801133) and W...
Estudios de Casos y Controles,
Catalasa/genética,
ADN (Citosina-5-)-Metiltransferasas/genética,
Metilación de ADN/genética,
Estudios de Asociación Genética,
Genotipo,
Metilenotetrahidrofolato Reductasa (NADPH2)/genética,
MicroARNs/genética,
Periodontitis/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Polimorfismo de Longitud del Fragmento de Restricción,
Superóxido Dismutasa-1/genética
Introducción. Sobre la base de un caso clínico, se presenta la descripción del cuadro intersticial por deficiencia de ABCA3, de una paciente de catorce años de edad, en seguimiento durante doce años. Método. Evaluación clínica con extensos estudios para descartar otras patologías semejantes. El ...
ABSTRACT Purpose: To investigate the potential associations between keratoconus and catalase rs1001179, superoxide dismutase 2 rs4880, and glutathione peroxidase 1 rs1050450 gene polymorphisms in a Turkish population. Methods: The study group included 121 unrelated keratoconus patients and 94 unrelate...
Estudios de Casos y Controles,
Catalasa/genética,
Frecuencia de los Genes,
Estudios de Asociación Genética,
Técnicas de Genotipaje,
Glutatión Peroxidasa/genética,
Queratocono/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Nucleótido Simple/genética,
Valores de Referencia,
Factores de Riesgo,
Superóxido Dismutasa/genética,
Turquía
Abstract Background: Palmoplantar pustulosis is considered to be a localized pustular psoriasis confined to the palms and soles. Mutation of the IL36RN gene, encoding interleukin-36 receptor antagonist (IL-36Ra), is associated with generalized pustular psoriasis, but IL36RN mutations in Chinese palmopla...
Análisis del Polimorfismo de Longitud de Fragmentos Amplificados,
Pueblo Asiatico/genética,
China,
Dermatosis del Pie/genética,
Dermatosis del Pie/patología,
Estudios de Asociación Genética,
Dermatosis de la Mano/genética,
Dermatosis de la Mano/patología,
Heterocigoto,
Interleucinas/genética,
Mutación,
Fenotipo,
Psoriasis/genética,
Psoriasis/patología,
Análisis de Secuencia de ADN,
Estadísticas no Paramétricas
ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of st...
