Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
Braz. j. med. biol. res; 51 (1), 2018
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor...
Análisis de Varianza, Antineoplásicos Inmunológicos/farmacología, Western Blotting, Células CACO-2, Línea Celular Tumoral, Cetuximab/farmacología, Neoplasias del Colon/tratamiento farmacológico, Exosomas/efectos de los fármacos, Fosfohidrolasa PTEN/efectos de los fármacos, Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos, Sales de Tetrazolio, Factores de Tiempo