LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Sericin as treatment of obesity: morphophysiological effects in obese mice fed with high-fat diet

Kunz, Regina Inês; Capelassi, Angélica Novi; Alegre-Maller, Ana Cláudia Paiva; Bonfleur, Maria Lúcia; Ribeiro, Lucinéia de Fátima Chasko; Costa, Rose Meire; Natali, Maria Raquel Marçal.

Einstein (São Paulo, Online); 18 (), 2020

ABSTRACT Objective To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet. Methods Male C57Bl6 mice aged 9 weeks were allocated to one of two groups - Control and Obese, and fed a standard or hig...

Tejido Adiposo/patología, Fármacos Antiobesidad/farmacología, Fármacos Antiobesidad/uso terapéutico, Peso Corporal/efectos de los fármacos, Colesterol/análisis, Dieta Alta en Grasa/efectos adversos, Ingestión de Alimentos/efectos de los fármacos, Hígado Graso/patología, Tránsito Gastrointestinal/efectos de los fármacos, Prueba de Tolerancia a la Glucosa, Hígado/metabolismo, Ratones Endogámicos C57BL, Ratones Obesos, Obesidad/tratamiento farmacológico, Obesidad/etiología, Obesidad/fisiopatología, Reproducibilidad de los Resultados, Sericinas/farmacología, Factores de Tiempo, Resultado del Tratamiento, Triglicéridos/análisis, Aumento de Peso/efectos de los fármacos, Sericinas/uso terapéutico

Fulltext

Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity ...