SUMMARY: In this study we aimed to examine the effect of novel vasodilatory drug Riociguat co-administration along resveratrol to recover neurodegeneration in experimental stroke injury. For that purpose, thirty-five adult female rats were divided into five groups (Control, MCAO, MCAO + R, MCAO + BAY, MC...
Accidente Cerebrovascular/tratamiento farmacológico,
Pirazoles/administración & dosificación,
Pirimidinas/administración & dosificación,
Activadores de Enzimas/administración & dosificación,
Resveratrol/administración & dosificación,
Apoptosis/efectos de los fármacos,
Inflamación,
Modelos Animales,
Guanilato Ciclasa/efectos de los fármacos,
Fármacos Neuroprotectores,
Ensayo de Inmunoadsorción Enzimática,
Inmunohistoquímica,
Quimioterapia Combinada,
Accidente Cerebrovascular/patología,
Arteria Cerebral Media,
Arteriopatías Oclusivas,
Interleucina-1beta/análisis,
Interleucina-6/análisis
SUMMARY: Spinal cord injury (SCI) usually arises from compression due to traffic accidents and falls, resulting in varying degrees of movement, sensory loss, and possible paralysis. Glabridin (Gla) is a natural compound derived from licorice. It significantly affects drug development and medicine because...
Purpose: To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion. Methods: SOD2 transgenic mice were engineered using transcription activator-like effector nu...
Purpose: To evaluate the neuroprotective effect of resveratrol, urapidil, and a combined administration of these drugs against middle cerebral artery occlusion (MCAO) induced ischemia/reperfusion (IR) injury model in rats. Methods: Thirty-five rats were divided into five groups of seven animals each. Ani...
The neuroprotective effect of flower and fruit parts of Capparis ovata Desf. var. palaestina Zoh. plant was investigated in H2O2-induced cytotoxicity in SH-SY5Y cells. The cells were treated with H2O2 alone or pretreated with flower (COMFL) and fruit extract (COMFR) of C. ovatavar. palaesti...
Abstract Background The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated. Activation of Nuclear factor erythroid 2-related factor (Nrf2) and Heme Oxygenase-1 (HO-1) represents a major antioxidant-de...
Antioxidantes/metabolismo,
Antioxidantes/farmacología,
Isquemia Encefálica,
Dexmedetomidina/farmacología,
Hemo Oxigenasa (Desciclizante)/farmacología,
Hemo-Oxigenasa 1/metabolismo,
Hemo-Oxigenasa 1/farmacología,
Ataque Isquémico Transitorio,
Factor 2 Relacionado con NF-E2/metabolismo,
Factor 2 Relacionado con NF-E2/farmacología,
Fármacos Neuroprotectores/farmacología,
Estrés Oxidativo,
Proteína Quinasa C/metabolismo,
Daño por Reperfusión/prevención & control,
Proteína Quinasa C/farmacología
Abstract Acai (Euterpe oleracea Mart.) and guarana (Paullinia cupana Kunth) are native species from the Amazon Forest that in folk medicine are used to treat several diseases due to their anti-inflammatory and antioxidant properties. This review brings together findings from different studies on the pote...
ABSTRACT Positron emission tomography (PET) is a non-invasive nuclear imaging technique that uses radiotracers to track cell activity. The radiopharmaceutical 18F-fluoro-2-deoxyglucose ([18F] FDG) is most commonly used in nuclear medicine for the diagnosis of various diseases, including stroke. A stroke ...
BACKGROUND: The underlying mechanism of Parkinson's disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are transcription factors involved in the control of numerous pathways. Specifically, PPARβ/...
Purpose: Intravenous anesthetics have excellent analgesic activity without inducing the side effect in the respiratory system. The aim and objective of the current experimental study was to access the neuroprotective effect of sevoflurane against isoflurane induced cognitive dysfunction in rats. Methods:...
