LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Applicability of [18F]FDG/PET for investigating rosmarinic acid preconditioning efficacy in a global stroke model in mice

Santos, Elaine Vasconcelos dos; Schirmer, Brígida Gomes de Almeida; Pereira, Jousie Michel; Cardoso, Natane Vitória Silva; Malamut, Carlos; Oliveira, Mércia Liane de.

Braz. J. Pharm. Sci. (Online); 59 (), 2023

ABSTRACT Positron emission tomography (PET) is a non-invasive nuclear imaging technique that uses radiotracers to track cell activity. The radiopharmaceutical 18F-fluoro-2-deoxyglucose ([18F] FDG) is most commonly used in nuclear medicine for the diagnosis of various diseases, including stroke. A stroke ...

Tomografía de Emisión de Positrones/instrumentación, Accidente Cerebrovascular/patología, Radiofármacos/farmacología, ddcs0285700, Fármacos Neuroprotectores/agonistas, Isquemia Encefálica/patología, d0090170, d0154270

Fulltext

Neuroprotective effects of sinapic acid involve the iron regulatory role on the rotenone-induced Parkinson's disease model

Abstract In the last decades, ferroptosis and its relationship with Parkinson's disease have gained significant attention. Compounds that affect ferroptosis and iron-dependent pathways in particular, have possible candidates for study in this context.Sinapic acid is an iron-chelator and high antioxidant ...