The neuroprotective effect of flower and fruit parts of Capparis ovata Desf. var. palaestina Zoh. plant was investigated in H2O2-induced cytotoxicity in SH-SY5Y cells. The cells were treated with H2O2 alone or pretreated with flower (COMFL) and fruit extract (COMFR) of C. ovatavar. palaesti...
Abstract Background The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated. Activation of Nuclear factor erythroid 2-related factor (Nrf2) and Heme Oxygenase-1 (HO-1) represents a major antioxidant-de...
Antioxidantes/metabolismo,
Antioxidantes/farmacología,
Isquemia Encefálica,
Dexmedetomidina/farmacología,
Hemo Oxigenasa (Desciclizante)/farmacología,
Hemo-Oxigenasa 1/metabolismo,
Hemo-Oxigenasa 1/farmacología,
Ataque Isquémico Transitorio,
Factor 2 Relacionado con NF-E2/metabolismo,
Factor 2 Relacionado con NF-E2/farmacología,
Fármacos Neuroprotectores/farmacología,
Estrés Oxidativo,
Proteína Quinasa C/metabolismo,
Daño por Reperfusión/prevención & control,
Proteína Quinasa C/farmacología
BACKGROUND: The underlying mechanism of Parkinson's disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are transcription factors involved in the control of numerous pathways. Specifically, PPARβ/...
ABSTRACT Purpose: Subarachnoid hemorrhage (SAH) is a common complication of cerebral vascular disease. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy. Autophagy is a programmed cell death mechanism that plays...
ABSTRACT Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major cause of death and disability with a huge economic burden worldwide. Cerebrolysin (CBL) has been previously used as a nootropic drug. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death af...
Aminoácidos,
Apoptosis,
Hemorragia Cerebral/tratamiento farmacológico,
Glucógeno Sintasa Quinasa 3 beta/farmacología,
Ratones Endogámicos C57BL,
Necroptosis,
Neuronas/metabolismo,
Neuroprotección,
Fármacos Neuroprotectores/farmacología,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Transducción de Señal
It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies. The present study investigated whether the anti-apoptotic effect can account for the neuroprotective action of ZNS on cerebral ischemia. Neuronal ...
Tirapelli, Daniela P. C;
Cirino, Mucio Luiz de Assis;
Carvalho, Camila A. Melo de;
Novais, Paulo Cezar;
Figueredo, Rafael Zimak;
Porsani, Lucas Barbosa;
Gula, Isabella Stracieri;
Rodrigues, Andressa Romualdo;
Silva, Jairo Pinheiro da;
Pereira, Adriana Lis;
Lizarte Neto, Fermino Sanches;
Schimming, Bruno Cesar;
Tazima, Maria de Fátima Galli Sorita;
Fazan, Valéria de Paula Sassoli;
Carlotti-Jr, Carlos Gilberto;
Tirapelli, Luis Fernando;
Colli, Benedicto Oscar.
This study aimed to investigate the morphometric and the pattern of protein and gene expression related to the extrinsic apoptotic pathway in experimental focal cerebral ischemia and the hole of neuroprotection with hypothermia and ketoprofen. For this analysis, 120 rats were randomly divided into 3 grou...
Isquemia Encefálica/terapia,
Isquemia Encefálica/genética,
Apoptosis/genética,
Hipotermia Inducida,
Cetoprofeno/farmacología,
Fármacos Neuroprotectores/farmacología,
Isquemia Encefálica/patología,
Caspasa 8/genética,
Caspasa 3/genética,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Isquemia Encefálica/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa
Abstract Purpose To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions. Methods Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, tr...
Astrocitos/efectos de los fármacos,
Lesiones Traumáticas del Encéfalo/patología,
Lesiones Traumáticas del Encéfalo/prevención & control,
Lesiones Traumáticas del Encéfalo/cirugía,
Proteínas de Unión al Calcio/análisis,
Cinamatos/farmacología,
Craneotomía/métodos,
Depsidos/farmacología,
Proteína Ácida Fibrilar de la Glía/análisis,
Glutatión Peroxidasa/análisis,
Inmunohistoquímica,
Malondialdehído/análisis,
Proteínas de Microfilamentos/análisis,
Fármacos Neuroprotectores/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados
Abstract In live organisms, there is a balance between the production of reactive oxygen species (ROS) and their neutralization. The increased level of these species leads to a condition called redox imbalance. The aim of this study was to evaluate the protective action of isobenzofuranones in primary cu...
Neuronal cell damage is often caused by prolonged misuse of Methylphenidate (MPH). Topiramate (TPM) carries neuroprotective properties but its assumed mechanism remains unclear. The present study evaluates in vivo role of various doses of TPM and its mechanism against MPH-induced motor activity and relat...
