Current pharmacotherapy of Parkinson's disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients' quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituent of can...
Neurodegeneration is a progressive loss of neurons both structurally and functionally causing neuronal cell death ultimately leading to development of various neurodegenerative diseases. Due to poor pharmacokinetic profile of neurotrophins, there still remains a challenge in their...
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is a common disease that occurs during the perinatal period. The primary cause of neonatal HIE is related to fetal intrauterine anoxia. Carbamylated erythropoietin (CEPO), a derivative of erythropoietin (EPO), does not exert any erythropoietic effect; how...
Las encefalitis autoinmunes son un nuevo grupo de enfermedades de gran trascendencia clínica y terapéutica debido a la buena respuesta en gran parte de los casos a la terapia inmunomoduladora indicada, con un gran porcentaje de curación, sin secuelas neurológicas importantes (cognitivo, motor, crisis...
Anticuerpos/sangre,
Autoanticuerpos/sangre,
Enfermedades Autoinmunes/diagnóstico,
Enfermedades Autoinmunes/tratamiento farmacológico,
Biomarcadores/sangre,
Encefalitis/diagnóstico,
Encefalitis/tratamiento farmacológico,
Enfermedad de Hashimoto/sangre,
Enfermedad de Hashimoto/diagnóstico,
Enfermedad de Hashimoto/tratamiento farmacológico,
Metilprednisolona/uso terapéutico,
Fármacos Neuroprotectores/uso terapéutico,
Rituximab/uso terapéutico
ABSTRACT Objective To investigate the impact of epidemiological and clinical factors on the benefit of riluzole in patients with amyotrophic lateral sclerosis (ALS). Methods The survival rate of 578 patients with ALS (1999-2011) was analyzed by descriptive statistics and Kaplan-Meier curves. Consider...
Esclerosis Amiotrófica Lateral/diagnóstico,
Esclerosis Amiotrófica Lateral/tratamiento farmacológico,
Esclerosis Amiotrófica Lateral/mortalidad,
Brasil/epidemiología,
Parálisis Bulbar Progresiva/diagnóstico,
Electromiografía,
Fármacos Neuroprotectores/uso terapéutico,
Estudios Prospectivos,
Riluzol/uso terapéutico,
Factores Sexuales,
Tasa de Supervivencia
ABSTRACT Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary an...
Abstract This study was designed to investigate whether dexmedetomidine and thiopental have cerebral protective effects after focal cerebral ischemia in rats. Thirty male Sprague Dawley rats were randomly assigned to three groups: control group (Group C, n = 10), dexmedetomidine group (Group D, n = 10), ...
El evento cerebrovascular isquémico es una de las principales patologías crónicas de mayor prevalencia
a nivel mundial, con tasas altas de mortalidad y discapacidad, con impacto significativo en el ámbito laboral, familiar, social, personal y sanitario. El campo de la neurocirugía endovascular se ha...
El ácido valproico, que además de ser un conocido antiepiléptico, una serie de trabajos en los últimos años lo proponen como un agente neuroprotector. En éste trabajo se investigó primeramente, si el ácido valproico protege a las neuronas del daño producido por el estrés oxidativo inducido por ...
Resumo O processo de transição demográfica brasileiro tem levado a substancial envelhecimento populacional e a aumento na prevalência de síndromes demenciais, entre as quais se destaca a Doença de Alzheimer (DA). Desde 2002, o tratamento farmacológico da doença possui Protocolo Clínico e Diretri...
