A periodontite é caracterizada pela inflamação nos tecidos periodontais e consequente perda das estruturas de suporte do dente: osso alveolar, cemento e ligamento periodontal, podendo levar à perda de dentes. A homeostase do tecido ósseo é gerida fundamentalmente pela regulação da via de sinaliza...
SUMMARY: Stroke is the leading cause of acquired physical disability in adults and second leading cause of mortality throughout the world. Treatment strategies to curb the effects of stroke would be of great benefit. Pongamia pinnata is a recent attraction in medicine, owing to its abundant medicinal ben...
Millettia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Accidente Cerebrovascular/tratamiento farmacológico,
Ratas Wistar,
Modelos Animales de Enfermedad,
Corteza Cerebral/efectos de los fármacos,
Isquemia Encefálica/tratamiento farmacológico,
Factor Neurotrófico Derivado del Encéfalo/genética,
Factor Neurotrófico Derivado de la Línea Celular Glial/genética,
Factor 1 Inducible por Hipoxia/genética,
FN-kappa B,
Administración Oral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Crecimiento Nervioso/administración & dosificación
Purpose: To investigate inflammation and cell adhesion molecules in the vagina after ovarian ischemia-reperfusion (IR) injury. Methods: 20 Wistar albino female rats were divided into two groups: control, and IR groups. In IR group, blood flow was restricted for 2 hours for ovarian ischemia. Then, tissues...
Purpose: Reflux esophagitis is a condition characterized by inflammation and irritation of the esophagus, resulting from the backflow of stomach acid and other gastric contents into the esophagus. Columbianadin is a coumarin derivative that exhibits anti-inflammatory and antioxidant effects. In this stud...
SUMMARY: The aim of this study is to reveal the gonadoprotective effects of myricetin (MYC), which has many biological properties, on cisplatin (CP)-induced testicular damage in rats. For this purpose, 40 male Wistar albino rats were divided into 4 groups as Control (group given no treatment), MYC (group...
Flavonoides/administración & dosificación,
Flavonoides/farmacología,
Testículo/lesiones,
Testículo/efectos de los fármacos,
Cisplatino/toxicidad,
Antineoplásicos/toxicidad,
Respuesta al Choque Térmico,
Inflamación,
Ratas Wistar,
Receptor Toll-Like 4,
FN-kappa B,
Inmunohistoquímica,
Etiquetado Corte-Fin in Situ
Taha, Medhat;
Ibrahim, Mohie Mahmoud;
Elazab, Sara T;
Badawy, Alaa. M;
Abdelsalam, Ramy A;
Saati, Abdullah A;
Qusty, Naeem F;
Babateen, Omar;
Abdelbagi, Omer;
Hendawy, M.
SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...
Antraquinonas/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Daño por Reperfusión/tratamiento farmacológico,
Antraquinonas/inmunología,
Células Dendríticas/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Enfermedades Renales/tratamiento farmacológico,
Daño por Reperfusión/inmunología,
Enfermedades Renales/inmunología,
Inyecciones Intraperitoneales,
FN-kappa B/metabolismo,
Receptor Toll-Like 4/metabolismo,
Transducción de Señal,
Estrés Oxidativo,
Inflamación,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Interleucina-1beta/metabolismo,
Citometría de Flujo,
d0201690,
d0200110
The current study was conducted to determine the neuroprotective role and mechanism of action of Linalool (LIN) in SCI. The SCI in Sprague-Dawley (SD) rats was induced by weight-drop contusion model. Results of the suggested that LIN showed improvement in the locomo...
Monoterpenos Acíclicos/administración & dosificación,
Monoterpenos Acíclicos/farmacología,
Traumatismos de la Médula Espinal/tratamiento farmacológico,
Ratas Sprague-Dawley,
Estrés Oxidativo/efectos de los fármacos,
Inflamación,
Western Blotting,
FN-kappa B/antagonistas & inhibidores,
Receptor Toll-Like 4/antagonistas & inhibidores,
Transducción de Señal/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática
SUMMARY: Gastrin plays a vital role in the development and progression of gastric cancer (GC). Its expression is up-regulated in GC tissues and several GC cell lines. Yet, the underlying mechanism remains to be investigated. Here, we aim to investigate the role and mechanism of gastrin in GC proliferatio...
Gastrinas/metabolismo,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Apoptosis,
Especies Reactivas de Oxígeno,
Anexina A2/metabolismo,
Proliferación Celular,
FN-kappa B,
Mitocondrias/patología,
Citometría de Flujo,
Técnica del Anticuerpo Fluorescente,
Espectrometría de Masas,
Línea Celular Tumoral,
Inmunoprecipitación,
Carcinogénesis
SUMMARY: Paracetamol (known as acetaminophen, or APAP) poisoning causes acute liver damage that can lead to organ failure and death. We sought to determine that APAP overdose can augment tumor necrosis factor-alpha (TNF-α)/ nuclear factor kappa B (NF-kB)/induced nitic oxide synthase (iNOS) axis-medi...
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico,
Acetaminofén/toxicidad,
Quercetina/administración & dosificación,
Resveratrol/administración & dosificación,
Enfermedad Aguda,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
FN-kappa B/antagonistas & inhibidores,
Óxido Nítrico Sintasa/antagonistas & inhibidores,
Quimioterapia Combinada,
Sobredosis de Droga,
Ratas Sprague-Dawley,
Sustancias Protectoras
Purpose: To analyze the potential of tumor necrosis factor-α (TNF-α) and factor nuclear kappa B (NF-κB) as colorectal cancer (CRC) biomarkers in an experimental model of intestinal carcinogenesis with 1,2-dimethyhydrazine (1,2-DMH). Methods: Twenty-four male Wistar rats were divided into two groups: s...
