LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Treatment with β-elemene combined with paclitaxel inhibits growth, migration, and invasion and induces apoptosis of ovarian cancer cells by activation of STAT-NF-κB pathway

Xiaomeng, Fu; Lei, Lv; Jinghong, An; Juan, Jiang; Qi, Yue; Dandan, Yuan.

Braz. j. med. biol. res; 53 (6), 2020

In this study, we aimed to analyze the anti-cancer effects of β-elemene combined with paclitaxel for ovarian cancer. RT-qPCR, MTT assay, western blot, flow cytometry, and immunohistochemistry were used to analyze in vitro and in vivo anti-cancer effects of combined treatment of β-elemene and pa...

Apoptosis/efectos de los fármacos, Western Blotting, Línea Celular Tumoral, Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Inmunohistoquímica, Ratones Endogámicos BALB C, FN-kappa B/efectos adversos, FN-kappa B/metabolismo, Neoplasias Ováricas/tratamiento farmacológico, Neoplasias Ováricas/metabolismo, Neoplasias Ováricas/patología, Paclitaxel/administración & dosificación, Reacción en Cadena en Tiempo Real de la Polimerasa, Sesquiterpenos/administración & dosificación, Transducción de Señal, Transfección

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Short-term insulin intensive therapy decreases MCP-1 and NF-κB expression of peripheral blood monocyte and the serum MCP-1 concentration in newlydiagnosed type 2 diabetics

Lin, Yang; Ye, Shandong; He, Yuanyuan; Li, Sumei; Chen, Yan; Zhai, Zhimin.

Arch. endocrinol. metab. (Online); 62 (2), 2018

ABSTRACT Objective To observe the effect of short-term insulin intensive treatment on the monocyte chemoattractant protein-1 (MCP-1) as well as on the nuclear factor-kappa B (NF-κB) expression of peripheral blood monocyte. This is also in addition to observing the serum MCP-1 level in newlydiagnose...

Estudios de Casos y Controles, Quimiocina CCL2/sangre, Quimiocina CCL2/efectos de los fármacos, Diabetes Mellitus Tipo 2/sangre, Diabetes Mellitus Tipo 2/tratamiento farmacológico, Ensayo de Inmunoadsorción Enzimática, Citometría de Flujo, Inflamación/prevención & control, Insulina/administración & dosificación, Monocitos/química, FN-kappa B/sangre, FN-kappa B/efectos adversos

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Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

Gan, Zhongyuan; Huang, Dan; Jiang, Jiaye; Li, Yuan; Li, Hanqing; Ke, Yan.

Braz. j. med. biol. res; 51 (11), 2018

Hypertensive renal damage generally occurs during the middle and late stages of hypertension, which is typically characterized by proteinuria and renal inflammation. Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been widely used for therapy of arterial hypertension and cardiovascular d...

Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico, Antihipertensivos/uso terapéutico, Captopril/uso terapéutico, Hipertensión/complicaciones, Hipertensión/tratamiento farmacológico, FN-kappa B/efectos adversos, Nefritis/etiología, Nefritis/prevención & control, Proteinuria/etiología, Proteinuria/prevención & control, Ratas Endogámicas SHR, Ratas Endogámicas WKY, Transducción de Señal

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