LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Astragaloside IV alleviates stroke-triggered early brain injury by modulating neuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway

Zhang, Chunlei; Shi, Zhonghua; Xu, Qinyi; He, Jianqing; Chen, Lei; Lu, Zehua; Huan, Qiaohua; Wang, Yuhai; Cui, Gang.

Acta cir. bras; 38 (), 2023

Purpose: Stroke is an acute cerebrovascular disease. Astragaloside IV (AS-IV) is an active ingredient extracted from Astragalus membranaceus with an established therapeutic effect on central nervous system diseases. This study examined the neuroprotective properties and possible mechanisms of AS-IV in st...

Planta del Astrágalo/química, Saponinas, Extractos Vegetales/administración & dosificación, Ferroptosis, Factor 2 Relacionado con NF-E2/análisis, Neuroinmunomodulación, Accidente Cerebrovascular/complicaciones, Lesiones Encefálicas/terapia

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Pin1 aggravates renal injury induced by ischemia and reperfusion in rats via Nrf2/HO-1 mediated endoplasmic reticulum stress

Purpose: To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism. Methods: By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by using molecular assays. Results: In renal I/R, en...