LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The antioxidant effect of preischemic dexmedetomidine in a rat model: increased expression of Nrf2/HO-1 via the PKC pathway

Park, Yong-Hee; Park, Hee-Pyoung; Kim, Eugene; Lee, Hannah; Hwang, Jung-Won; Jeon, Young-Tae; Lim, Young-Jin.

Braz. J. Anesth. (Impr.); 73 (2), 2023

Abstract Background The precise underlying mechanism of antioxidant effects of dexmedetomidine-induced neuroprotection against cerebral ischemia has not yet been fully elucidated. Activation of Nuclear factor erythroid 2-related factor (Nrf2) and Heme Oxygenase-1 (HO-1) represents a major antioxidant-de...

Antioxidantes/metabolismo, Antioxidantes/farmacología, Isquemia Encefálica, Dexmedetomidina/farmacología, Hemo Oxigenasa (Desciclizante)/farmacología, Hemo-Oxigenasa 1/metabolismo, Hemo-Oxigenasa 1/farmacología, Ataque Isquémico Transitorio, Factor 2 Relacionado con NF-E2/metabolismo, Factor 2 Relacionado con NF-E2/farmacología, Fármacos Neuroprotectores/farmacología, Estrés Oxidativo, Proteína Quinasa C/metabolismo, Daño por Reperfusión/prevención & control, Proteína Quinasa C/farmacología

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Effects of ATRA on diabetic rats with renal ischemia-reperfusion injury

Abstract Purpose To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats. Methods Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A g...