LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

CFH Y402H polymorphism and response to intravitreal Ranibizumab in brazilian patients with neovascular age-related macular degeneration

Objective: To investigate the association between CFH gene polymorphism and response to ranibizumab in Brazilian patients with neovascular age-related macular degeneration (AMD). Methods: 95 patients were genotyped for the CFH rs1061170 (Y402H) single nucleotide polymorphism. Patients with neovascular AM...

Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Veloso, Carlos Eduardo dos Reis; Almeida, Luciana Negrão Frota de; De Marco, Luiz Armando; Vianna, Raul Nunes Galvarro; Nehemy, Márcio Bittar.

Rev. bras. oftalmol; 71 (3), 2012

Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we...

Degeneración Macular/genética, Degeneración Macular/tratamiento farmacológico, Degeneración Macular, Predisposición Genética a la Enfermedad, Polimorfismo Genético/genética, Genotipo, Factor H de Complemento/genética, Fotoquimioterapia/métodos, Envejecimiento/genética, Neovascularización Coroidal/genética, Fármacos Fotosensibilizantes/uso terapéutico, Factor A de Crecimiento Endotelial Vascular/genética, Antioxidantes/uso terapéutico, Zinc/uso terapéutico, Inhibidores de la Angiogénesis/uso terapéutico, Bevacizumab/uso terapéutico, Ranibizumab/uso terapéutico

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