SUMMARY: We aimed to investigate the protective effect of linoleic acid on liver toxicity induced by methotrexate. The study was carried out in partnership with the Department of Anatomy and Department of Medical Pharmacology of Çukurova University Faculty of Medicine, using the laboratory facilities of...
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Ácido Linoleico/administración & dosificación,
Metotrexato/toxicidad,
Hepatocitos/efectos de los fármacos,
Sustancias Protectoras,
Hígado/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática,
Células Cultivadas,
Hígado/citología,
Factor Inductor de la Apoptosis,
Chaperón BiP del Retículo Endoplásmico,
Caspasa 3,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Antimetabolitos Antineoplásicos/toxicidad
Sarraipo, Vagner Schiavoni;
Lizarte Neto, Fermino Sanches;
Carvalho, Camila Albuquerque Mello de;
Silva, Jairo Pinheiro da;
Durand, Marina Toledo;
Schimming, Bruno Cezar;
Martinez, Marcelo;
Galli, Maria de Fátima Tazima Sorita;
Buono, Fabianna de Oliveira;
Tiezzi, Maria Fernanda Barbirato da Mata;
Novais, Paulo Cezar;
Gula, Isabella Stracieri;
Thomazini, José Antônio;
Fazan, Valeria Paula Sassoli;
Rodrigues, Andressa Romualdo;
Tirapelli, Daniela Pretti da Cunha;
Cirino, Mucio Luiz de Assis;
Molina, Carlos Augusto Fernandes;
Junior, Silvio Tucci;
Tirapelli, Luis Fernando.
SUMMARY: Previous studies from our group described the consequences of using ethanol on penile erection. Nevertheless, the molecular mechanisms surrounding microRNAs, apoptosis process and their relationship with erectile dysfunction associated with alcohol consumption are still poorly understood. The ob...
Alcoholismo/metabolismo,
Disfunción Eréctil/metabolismo,
Apoptosis,
MicroARNs/metabolismo,
Factor Inductor de la Apoptosis/metabolismo,
Pene/química,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ratas Wistar,
MicroARNs/análisis,
Factor Inductor de la Apoptosis/análisis,
Alcoholismo/fisiopatología,
Disfunción Eréctil/fisiopatología,
Pene/fisiopatología,
Reacción en Cadena en Tiempo Real de la Polimerasa,
MicroARNs/genética,
Factor Inductor de la Apoptosis/genética
Abrahão, Dayana Pousa Siqueira;
Lizarte Neto, Fermino Sanches;
Rodrigues, Andressa Romualdo;
Cirino, Múcio Luiz de Assis;
Silva, Jairo Pinheiro da;
Sarraipo, Vagner Schiavoni;
Carvalho, Camila Albuquerque Melo de;
Tazima, Maria de Fátima Galli Sorita;
Carlotti-Jr, Carlos Gilberto;
Colli, Benedicto Oscar;
Tirapelli, Luís Fernando;
Tirapelli, Daniela Pretti da Cunha.
The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 proteins in rats subm...
Abstract Objective To determine the role of caspase-3, apoptosis-inducing factor (AIF), and Bcell lymphoma-2 (Bcl-2) expressions in term premature rupture of membrane (PROM). Methods An analytic observational study with case-control design was conducted, involving 52 subjects (37-42 weeks of gestatio...
Excessive exposure to ultraviolet (UV) rays can cause damage of the skin and may induce cancer, immunosuppression, photoaging, and inflammation. The long non-coding RNA (lncRNA) HOX antisense intergenic RNA (HOTAIR) is involved in multiple human biological processes. However, its role in UVB-induced kera...
Apoptosis/fisiología,
Apoptosis/efectos de la radiación,
Factor Inductor de la Apoptosis/metabolismo,
Supervivencia Celular/fisiología,
Expresión Génica,
Inflamación/etiología,
Interleucina-6/metabolismo,
Queratinocitos/metabolismo,
Queratinocitos/efectos de la radiación,
FN-kappa B/efectos de los fármacos,
FN-kappa B/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
ARN Largo no Codificante/metabolismo,
Factor de Necrosis Tumoral alfa/metabolismo,
Rayos Ultravioleta/efectos adversos,
Regulación hacia Arriba,
eIF-2 Quinasa/metabolismo
Abstract In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper solmsianum, was evaluated against the leukemic line K562. The cytotoxicity of grandisin (0.018 to 2.365 µM) was evaluated in K562 and normal peripheral blood lymphocytes by Trypan Blue Exclusion and M...
Background: SIVA is a transcriptional target of p53 that plays a potential role in the development and progression
of cancer. In this study, we analyzed SIVA1 and SIVA2 expression, and its association with clinical features and TP53 and MDM2 expression in bone marrow cells from healthy donors and myelody...
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease that shows apoptosis resistance. The introduction of imatinib mesylate has revolutionized the treatment of CML, but imatinib resistance may develop at any time and inevitably leads to disease progression. Synadenium umbellatum Pax. bel...
Medidas mensais da altura da pastagem, biomassa total, variações de biomassa viva e morta, a área específica foliar (SLA) e o Índice de Área de Folha (IAF) de fevereiro de 1999 a janeiro de 2005 na Fazenda Nossa Senhora (FNS) e em Rolim de Moura (RDM) entre Fevereiro a Março de 1999, Rondônia, Br...
