LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

A3 receptor agonist modulates IL-1β hippocampus levels in a rat model of neuropathic pain

Introduction: Considering the lack of specific treatments for neuropathic pain, this study aimed to evaluate the effect of a single dose of adenosine A3 receptor IB-MECA on inflammatory and neurotrophic parameters in rats subjected to a neuropathic pain model. Methods: 64 adult male Wistar rats were use...

Effect of Aloe vera on the expression of nerve factors, p75 and TrkA receptors in the hippocampus of diabetic rats

Mahabady, Mahmood Khaksary; Tapebur, Mohammad Bahrami; Mazaheri, Yazdan; Tabandeh, Mohammad Reza; Tabatabaei, Seyed Reza Fatemi.

Int. j. morphol; 39 (2), 2021

SUMMARY: Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate t...

Diabetes Mellitus Experimental/tratamiento farmacológico, Aloe/química, Extractos Vegetales/administración & dosificación, Extractos Vegetales/farmacología, Hipocampo/efectos de los fármacos, Factor de Crecimiento Nervioso/efectos de los fármacos, Administración Oral, Proteínas Tirosina Quinasas Receptoras/efectos de los fármacos, Proteínas Tirosina Quinasas Receptoras/genética, Factor de Crecimiento Nervioso/genética, Receptor de Factor de Crecimiento Nervioso/efectos de los fármacos, Receptor de Factor de Crecimiento Nervioso/genética, Ratas Wistar, Reacción en Cadena en Tiempo Real de la Polimerasa

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