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A3 receptor agonist modulates IL-1β hippocampus levels in a rat model of neuropathic pain

Cioato, Stefania Giotti; Medeiros, Liciane Fernandes; Lopes, Bettega Costa; Medeiros, Helouise Richardt; Caumo, Wolnei; Roesler, Rafael; Torres, Iraci LS.
Clin. biomed. res; 42 (2), 2022
Introduction: Considering the lack of specific treatments for neuropathic pain, this study aimed to evaluate the effect of a single dose of adenosine A3 receptor IB-MECA on inflammatory and neurotrophic parameters in rats subjected to a neuropathic pain model. Methods: 64 adult male Wistar rats were use...
Receptor de Adenosina A3/uso terapéutico, Neuralgia/diagnóstico, Neuralgia/metabolismo, Factor de Crecimiento Nervioso/genética, Factor de Crecimiento Nervioso/metabolismo
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Exogenous neuregulin-1 attenuates STZ-induced diabetic peripheral neuropathic pain in rats

Zhou, Fang; Xia, Zhongyuan; Liu, Kang; Zhou, Qin.
Acta cir. bras; 32 (1), 2017
Abstract Purpose: To investigate whether modulating NRG1 could attenuate diabetic neuropathic pain and analyze the underlying mechanism. Methods: Male SD rats were randomly divided into control group, diabetic group, NRG1 intervention group. After STZ-induced 2 weeks, NRG1 intervention daily for consec...
Diabetes Mellitus Experimental/tratamiento farmacológico, Neuropatías Diabéticas/tratamiento farmacológico, Neuralgia/tratamiento farmacológico, Neurregulina-1/uso terapéutico, Interleucina-1beta/metabolismo, Factor de Crecimiento Nervioso/metabolismo, Neuralgia/etiología, Distribución Aleatoria, Ratas Sprague-Dawley, Médula Espinal/metabolismo, Estreptozocina, Factor de Necrosis Tumoral alfa/metabolismo
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