LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Deciphering the functional role of EGR1 in Prostaglandin F2 alpha induced luteal regression applying CRISPR in corpus luteum of buffalo

Punetha, Meeti; Kumar, Sai; Paul, Avishek; Jose, Bosco; Bharati, Jaya; Sonwane, Arvind; Green, Jonathan A; Whitworth, Kristin; Sarkar, Mihir.

Biol. Res; 54 (), 2021

BACKGROUND: PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that are strongly linked to cellular proliferation, survival and apoptosis. Rapid eleva...

Búfalos, Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas, Cuerpo Lúteo/fisiología, Dinoprost/farmacología, Proteína 1 de la Respuesta de Crecimiento Precoz/fisiología, Luteólisis, Células Cultivadas, Cuerpo Lúteo/citología, Regulación de la Expresión Génica, Transducción de Señal, Factor de Crecimiento Transformador beta1/fisiología

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DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms

Abstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a ne...