ABSTRACT Purpose Herein we evaluated the effects of platelet concentrate (PC) and platelet-poor plasma (PPP) on bone repair using noncritical defects in the calvaria of rabbits and compared them to the presence of TGF-β1 and osteocalcin on reparative sites. Methods Five noncritical defects of 8.7 ...
OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with bovine serum albumin, lipopolysaccharide, and tetra...
Abstract This study evaluated the effect of a cyclopentenone-type PG, 15-Deoxy-Δ12,14-PG J2 (15d-PGJ2), and lectin (ScLL) on the viability of human gingival fibroblasts (HGFs), and on IL-6 and TGFβ-1 release by these fibroblasts, stimulated with lipopolysaccharide (LPS). HGFs were stimulated wi...
Análisis de Varianza,
Supervivencia Celular/efectos de los fármacos,
Células Cultivadas,
Ensayo de Inmunoadsorción Enzimática,
Fibroblastos/efectos de los fármacos,
Fibroblastos/metabolismo,
Encía/citología,
Interleucina-6/metabolismo,
Lipopolisacáridos/farmacología,
Lectinas de Plantas/farmacología,
Prostaglandina D2/análogos & derivados,
Prostaglandina D2/farmacología,
Valores de Referencia,
Estadísticas no Paramétricas,
Factores de Tiempo,
Factor de Crecimiento Transformador beta1/efectos de los fármacos,
Factor de Crecimiento Transformador beta1/metabolismo
Abstract Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF). Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sha...
Proteína Morfogenética Ósea 7/metabolismo,
Ácidos Cafeicos/uso terapéutico,
Modelos Animales de Enfermedad,
Regulación hacia Abajo,
Fallo Renal Crónico/inducido químicamente,
Fallo Renal Crónico/tratamiento farmacológico,
Fallo Renal Crónico/metabolismo,
Pruebas de Función Renal,
Lactatos/uso terapéutico,
Nefrectomía,
Ratas Sprague-Dawley,
Proteína smad6/metabolismo,
Factor de Crecimiento Transformador beta1/metabolismo,
Regulación hacia Arriba
The aim of this study was to investigate the role of kinase-insert domain-containing receptor (KDR) in intrauterine adhesions (IUA) and its mechanism. The Case group consisted of 92 patients diagnosed with IUA, and the Control group included 86 patients with uterine septum who had normal endometrium veri...
Western Blotting,
Estudios de Casos y Controles,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Ratas Wistar,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Índice de Severidad de la Enfermedad,
Transducción de Señal,
Proteínas Smad/genética,
Proteínas Smad/metabolismo,
Adherencias Tisulares/metabolismo,
Adherencias Tisulares/patología,
Factor de Crecimiento Transformador beta1/genética,
Factor de Crecimiento Transformador beta1/metabolismo,
Enfermedades Uterinas/metabolismo,
Enfermedades Uterinas/patología,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/genética,
Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo
Abstract Objective: To demonstrate the underlying mechanisms of aortic dissection compared to those of coronary artery disease in terms of the transforming growth factor-beta (TGF-β) signaling pathway. Methods: Twenty consecutive aortic dissection patients and 20 consecutive coronary artery diseas...
Abstract The aim of this study was to investigate salivary levels of TGFβ1 and proliferation/ maturation of epithelial mucosa cells in diabetic and hypertensive patients. Design: in this cross-sectional study, whole stimulated saliva and oral mucosa exfoliative cytology specimens were collected from...
Antígenos Nucleares,
Glucemia/metabolismo,
Estudios de Casos y Controles,
Estudios Transversales,
Diabetes Mellitus/sangre,
Diabetes Mellitus/metabolismo,
Diabetes Mellitus/patología,
Hipertensión/metabolismo,
Hipertensión/patología,
Mucosa Bucal/metabolismo,
Mucosa Bucal/patología,
Saliva/metabolismo,
Salivación,
Tasa de Secreción,
Factor de Crecimiento Transformador beta1/metabolismo
Abstract Purpose: To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level. Methods: Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the leve...
Abstract Purpose: To evaluate the effect of transforming growth factor β1 (TGF-β1) on tendon-to-bone reconstruction of rotator cuff tears. Methods: Seventy-two rat supraspinatus tendons were transected and reconstructed in situ. At 8 and 16 weeks, specimens of three groups; that is control,...
Fenómenos Biomecánicos,
Colágeno Tipo III/metabolismo,
Modelos Animales de Enfermedad,
Elasticidad/fisiología,
Ensayo de Inmunoadsorción Enzimática,
Fibroblastos/efectos de los fármacos,
Fibroblastos/fisiología,
Fuerza Muscular/fisiología,
Ratas Sprague-Dawley,
Manguito de los Rotadores/metabolismo,
Manguito de los Rotadores/cirugía,
Lesiones del Manguito de los Rotadores/metabolismo,
Lesiones del Manguito de los Rotadores/cirugía,
Traumatismos de los Tendones/tratamiento farmacológico,
Traumatismos de los Tendones/metabolismo,
Resistencia a la Tracción/fisiología,
Factor de Crecimiento Transformador beta1/metabolismo,
Factor de Crecimiento Transformador beta1/farmacología,
Factores de Crecimiento Endotelial Vascular/metabolismo,
Cicatrización de Heridas/efectos de los fármacos,
Cicatrización de Heridas/fisiología
OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We ex...
