LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome

The etiology of polycystic ovary syndrome (PCOS) is complex and the pathogenesis is not fully understood. Some studies have shown that dysregulation of ovarian granulosa cells may be related to abnormal follicles and excessive androgen in women with PCOS. Our team has also confirmed the high expression s...

Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells

Jia, Peng; Hu, Yu; Li, Gang; Sun, Yuqin; Zhao, Jian; Fu, Jie; Lu, Cuixia; Liu, Bin.

Acta cir. bras; 32 (5), 2017

Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a c...

Cromonas/farmacología, Colágeno Tipo III/metabolismo, Factor de Crecimiento del Tejido Conjuntivo/farmacología, Fibronectinas/metabolismo, Flavonoides/farmacología, Sistema de Señalización de MAP Quinasas/efectos de los fármacos, Células Cultivadas, Colágeno Tipo III/genética, Factor de Crecimiento del Tejido Conjuntivo/metabolismo, Fibronectinas/genética, Expresión Génica/efectos de los fármacos, Regulación de la Expresión Génica, Modelos Animales, Miocitos del Músculo Liso/citología, Miocitos del Músculo Liso/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, Proteínas Proto-Oncogénicas c-akt/metabolismo, Arteria Pulmonar/citología, Ratas Sprague-Dawley

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