SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
SUMMARY: The therapeutic effect of a granulocyte-colony stimulating factor (G-CSF) biosimilar drug, zarzio, on non-alcoholic fatty liver disease (NAFLD) in a rat model was investigated in this study. Thirty-two rats were randomly divided into four groups. Groups I and II were fed a standard laboratory di...
Factor Estimulante de Colonias de Granulocitos/administración & dosificación,
Biosimilares Farmacéuticos/administración & dosificación,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Factor de Necrosis Tumoral alfa/efectos de los fármacos,
Células Secretoras de Insulina/efectos de los fármacos,
Factor 2 Relacionado con NF-E2,
d0009750,
Dieta Alta en Grasa/efectos adversos,
Caspasa 3
SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/química,
Extractos Vegetales/farmacología,
Té/química,
Infliximab/farmacología,
Cisplatino/toxicidad,
Testículo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/química,
Inmunohistoquímica,
Malondialdehído/análisis,
Glutatión/análisis,
Testículo/patología
SUMMARY: The toxic effects of thioacetamide (TAA) and carbon tetrachloride on the human body are well recognized. In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxyge...
Metformina/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/inducido químicamente,
Tioacetamida/toxicidad,
Hipoglucemiantes/uso terapéutico,
Especies Reactivas de Oxígeno,
Antígenos Comunes de Leucocito,
Factor de Necrosis Tumoral alfa,
Inflamación,
Inmunohistoquímica,
Biomarcadores
Abstract Objective To analyze the serum levels of TNF-alpha and its TNF-R1 and TNF-R2 receptors in the blood of patients with low-impact fractures due to osteoporosis, comparing between genders and with healthy patients. Methods The present study was conducted with a blood sample of 62 patients, divi...
SUMMARY: Liver transplantation is the only available method to treat liver failure induced by chronic liver injury. We sought to determine whether the angiotensin-converting enzyme inhibitor, captopril, can inhibit the development of chronic liver injury induced by the hepatotoxic agent thioacetamide (TA...
Captopril/administración & dosificación,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Tioacetamida/toxicidad,
Inflamación,
Factor Nuclear 1-alfa del Hepatocito,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factor de Necrosis Tumoral alfa,
Inhibidores de la Metaloproteinasa de la Matriz,
Actinas,
Western Blotting,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Metaloproteinasa 9 de la Matriz,
Fibrosis
SUMMARY: Paracetamol (known as acetaminophen, or APAP) poisoning causes acute liver damage that can lead to organ failure and death. We sought to determine that APAP overdose can augment tumor necrosis factor-alpha (TNF-α)/ nuclear factor kappa B (NF-kB)/induced nitic oxide synthase (iNOS) axis-medi...
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico,
Acetaminofén/toxicidad,
Quercetina/administración & dosificación,
Resveratrol/administración & dosificación,
Enfermedad Aguda,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
FN-kappa B/antagonistas & inhibidores,
Óxido Nítrico Sintasa/antagonistas & inhibidores,
Quimioterapia Combinada,
Sobredosis de Droga,
Ratas Sprague-Dawley,
Sustancias Protectoras
La diabetes mellitus tipo 1 (DM1) es una enfermedad autoinmune que
genera dependencia exógena de insulina de forma permanente, presenta inflamación
subclínica crónica lo que conlleva a una elevación de marcadores de inflamación
como factor de necrosis tumoral alfa (TNF-α), proteína C reactiva (PC...
Diabetes Mellitus Tipo 1/metabolismo,
Índice de Masa Corporal,
Biomarcadores/análisis,
Hemoglobina Glucada/análisis,
Inflamación,
Factor de Necrosis Tumoral alfa/análisis,
Proteína C-Reactiva/análisis,
Interleucina-6/análisis,
Ensayo de Inmunoadsorción Enzimática,
Estado Nutricional,
Estadísticas no Paramétricas
Purpose: To analyze the potential of tumor necrosis factor-α (TNF-α) and factor nuclear kappa B (NF-κB) as colorectal cancer (CRC) biomarkers in an experimental model of intestinal carcinogenesis with 1,2-dimethyhydrazine (1,2-DMH). Methods: Twenty-four male Wistar rats were divided into two groups: s...
Abstract Acute pancreatitis (AP) is a life-unpleasant situation with contradictory and inadequate treatments. In this regard, the present study evaluated the effect of the possible pretreatment of lipase-pancreatin on L-arginine-induced AP. Forty adult mice were selected and divided into five groups: I) ...
