LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Expression of e-cadherin and wnt pathway proteins betacatenin, apc, tcf-4 and survivin in gastric adenocarcinoma: clinical and pathological implication

Lins, Rodrigo Rego; Oshima, Celina Tizuko Fujiyama; Oliveira, Levindo Alves de; Silva, Marcelo Souza; Mader, Ana Maria Amaral Antonio; Waisberg, Jaques.

ABCD (São Paulo, Impr.); 29 (4), 2016

ABSTRACT Background: Gastric cancer is the fifth most frequent cancer and the third most common cause of cancer-related deaths worldwide.It has been reported that Wnt/ betacatenin pathway is activated in 30-50% of these tumors. However,the deregulation of this pathway has not been fully elucidated. Ai...

Adenocarcinoma/metabolismo, Proteína de la Poliposis Adenomatosa del Colon/biosíntesis, Antígenos CD, Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/biosíntesis, Cadherinas/biosíntesis, Proteínas Inhibidoras de la Apoptosis/biosíntesis, Neoplasias Gástricas/metabolismo, Survivin, Factor de Transcripción 4, Factores de Transcripción/biosíntesis, Proteínas Wnt/biosíntesis, Vía de Señalización Wnt

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Immunohistochemistry expression of TCF4 protein on carcinoma, adenoma and non neoplastic colorectal mucosa

PURPOSE: To detect and quantify the immunoreactivity of TCF4 protein in colorectal carcinoma, colorectal adenoma and non-neoplasic colorectal epithelium. METHODS: We studied 129 individuals: 40 with colorectal cancer, 52 with colorectal adenoma and 37 with non-neoplastic colorectal epithelium. The colore...