Results: 2

MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy

Guo, Juanjuan; Han, Jie; Liu, Jieying; Wang, Shaoli.

Braz. j. med. biol. res; 53 (9), 2020

Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries. MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte inj...

Apoptosis, Diabetes Mellitus, Nefropatías Diabéticas, Factor de Transcripción E2F3, Glucosa, MicroARNs, Podocitos

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miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3

Gao, Weiwei; Zhou, Xiaoqing; Lin, Ruihua.

Braz. j. med. biol. res; 53 (5), 2020

Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers. However, the exact functions of miR-378a-5p and miR-630 in cataract are s...

Apoptosis, Western Blotting, Catarata/metabolismo, Progresión de la Enfermedad, Regulación hacia Abajo, Factor de Transcripción E2F3/metabolismo, Células Epiteliales/metabolismo, Citometría de Flujo, MicroARNs/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa

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