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MicroRNA-146a inhibition promotes total neurite outgrowth and suppresses cell apoptosis, inflammation, and STAT1/MYC pathway in PC12 and cortical neuron cellular Alzheimer's disease models

Ma, Yinghui; Ye, Jiye; Zhao, Li; Pan, Dongmei.
Braz. j. med. biol. res; 54 (5), 2021
This study aimed to explore the effect of microRNA (miR)-146a inhibition on regulating cell apoptosis, total neurite outgrowth, inflammation, and STAT1/MYC pathway in Alzheimer's disease (AD). PC12 and cortical neuron cellular AD models were constructed by Aβ1-42 insult. For the former model, nerve ...
Enfermedad de Alzheimer/genética, Apoptosis, Inflamación, MicroARNs/genética, Proyección Neuronal, Neuronas, Células PC12, Factor de Transcripción STAT1
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Nova mutação no gene STAT1 associada com candidíase mucocutânea crônica

Jobim, Mariana; Puel, Anne; Ewald, Gisele; Gil, Beatriz Chamun; Migaud, Melanie; Fagundes, Iara Santos; Cardone, Jaqueline; Jobim, Luiz.
Arq. Asma, Alerg. Imunol; 4 (3), 2020
Mutações no gene STAT1 (signal transducer and activator of transcription 1) têm sido identificadas como responsáveis pela maioria dos casos sindrômicos da candidíase mucocutânea crônica com herança autossômica dominante (AD). Nesse artigo, descrevemos uma menina de 7 anos que apresentou candidÃ...
Candidiasis Mucocutánea Crónica, Cryptococcus neoformans, Exoma, Factor de Transcripción STAT1, Inmunoglobulina A, Inmunoglobulina E, Inmunoglobulina G, Inmunoglobulina M, Linfocitos, Meningitis, Microsporum, Pacientes, Terapéutica, Exones, Antígenos CD4, Antígenos CD8, Autoanticuerpos
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Interferon-gamma signaling is downregulated in peripheral blood mononuclear cells from asthma patients

Nunes, Carolina Valadares; Fortunato, Laila Rigolin; Oliveira, Jhony Robison; Pereira, Aline Beatriz Mahler; Irie, Gabriela Rister Figueiredo; Tanaka, Sarah Cristina Sato Vaz; Silva, Marcos Vinícius; Silva-Jr, Wilson Carneiro; Balarin, Marly Aparecida Spadotto; Silva, Paulo Roberto; Teixeira, David Nascimento Silva; Rogerio, Alexandre Paula.
Arq. Asma, Alerg. Imunol; 4 (2), 2020
Introduction: Interferon-gamma (IFN-g) signaling is mediated by crosstalk of receptors, such as IFN-g receptor 1 (IFN-g R1), transcription factors, such as signal transducer and activator of transcription 1 (STAT1) and suppressors of cytokine signaling 1 (SOCS1). Here, we evaluated the role of IFN-g sign...
Asma, Interferón gamma, Pacientes, ARN Mensajero, Citometría de Flujo, Citocinas, Células, Factor de Transcripción STAT1, Ensayo de Inmunoadsorción Enzimática, Grupos Control, Quimiocinas
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Suppressor of cytokine signaling 1 expression during LPS-induced inflammation and bone loss in rats

Souza, João Antonio Chaves de; Nogueira, Andressa Vilas Boas; Souza, Pedro Paulo Chaves de; Oliveira, Guilherme José Pimentel Lopes de; Medeiros, Marcell Costa de; Garlet, Gustavo Pompermaier; Cirelli, Joni Augusto; Rossa-Junior, Carlos.
Braz. oral res. (Online); 31 (), 2017
Abstract This study aimed to characterize the dynamics of suppressor of cytokine signaling (SOCS1) expression in a rat model of lipopolysaccharide-induced periodontitis. Wistar rats in the experimental groups were injected three times/week with LPS from Escherichia coli on the palatal aspect of the first...
Pérdida de Hueso Alveolar/etiología, Pérdida de Hueso Alveolar/metabolismo, Pérdida de Hueso Alveolar/patología, Western Blotting, Inmunohistoquímica, Interferón gamma/análisis, Lipopolisacáridos, FN-kappa B/análisis, Periodontitis/etiología, Periodontitis/metabolismo, Periodontitis/patología, Ligando RANK/análisis, Distribución Aleatoria, Ratas Wistar, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Factor de Transcripción STAT1/análisis, Proteína 1 Supresora de la Señalización de Citocinas/análisis, Factores de Tiempo
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