Results: 6

Role of the bHLH transcription factor TCF21 in development and tumorigenesis

Lotfi, C F P; Passaia, B S; Kremer, J L.

Braz. j. med. biol. res; 54 (5), 2021

Transcription factors control, coordinate, and separate the functions of distinct network modules spatially and temporally. In this review, we focus on the transcription factor 21 (TCF21) network, a highly conserved basic-helix-loop-helix (bHLH) protein that functions to integrate signals and modulate ge...

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Carcinogénesis/genética, Diferenciación Celular, Transformación Celular Neoplásica/genética, Transducción de Señal

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Cochlea cell-specific marker expression upon in vitro Hes1 knockdown

Batissoco, A C; Lezirovitz, K; Zanatta, D B; Hemza, C R M L; Vasques, L R; Strauss, B E; Mingroni-Netto, R C; Haddad, L A; Bento, R F; Oiticica, J.

Braz. j. med. biol. res; 54 (7), 2021

NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from becoming hair cells. Genetic manipulation of this ...

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Diferenciación Celular, Cóclea, Células Ciliadas Auditivas, Órgano Espiral, Receptores Notch, Factor de Transcripción HES-1/genética

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A key for hypoxia genetic adaptation in alpaca could be a HIF1A truncated bHLH protein domain

Moraga, Fernando A; Figueroa, Felipe; Carrasco, Rocío; Moraga, Daniel.

J. health med. sci. (Print); 6 (2), 2020

Animals exposed to hypobaric hypoxia triggers a physiological hypoxia response via Hypoxia Inducible Factor (HIF) proteins that functions as transcriptional complexes. As the South American camelids inhabit at high Andean altitudes we have asked if they have developed genetic adaptations to live at high ...

Hipoxia, Adaptación Fisiológica/genética, Camélidos del Nuevo Mundo, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Subunidad alfa del Factor 1 Inducible por Hipoxia/genética

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Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia

Sadeghi, Fatemeh; Kardar, Gholam Ali; Bolouri, Mohammad Reza; Nasri, Farzad; Sadri, Maryam; Falak, Reza.

Biol. Res; 53 (), 2020

BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter of different genes, mainly through the bHLH domain and activates the transcription ...

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Hipoxia/metabolismo, Factor 1 Inducible por Hipoxia/metabolismo, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Western Blotting, Expresión Génica, Células HEK293, Hipoxia/genética, Factor 1 Inducible por Hipoxia/genética, Reacción en Cadena en Tiempo Real de la Polimerasa, Activación Transcripcional/genética

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Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor

Behfarjam, Farinaze; Jadali, Zohreh.

An. bras. dermatol; 93 (2), 2018

Abstract: IL-22 has been implicated in the pathogenesis of vitiligo. However, the role of aryl hydrocarbon receptor transcription factor that acts as a master regulator of IL-22-producing Th22 cells is not fully understood. The goal of this study was to investigate the expression pattern of aryl hydrocar...

Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Estudios de Casos y Controles, Expresión Génica, Interleucinas/análisis, ARN Mensajero/genética, Receptores de Hidrocarburo de Aril/genética, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Regulación hacia Arriba/genética, Vitíligo/genética

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New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells

França, Monica Malheiros; Lerario, Antonio M; Fragoso, Maria Candida BV; Lotfi, Claudimara Ferini Pacicco.

Clinics; 72 (6), 2017

OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 2...

Neoplasias de la Corteza Suprarrenal/genética, Neoplasias de la Corteza Suprarrenal/metabolismo, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Western Blotting, Línea Celular Tumoral, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica/genética, Immunoblotting, Reacción en Cadena en Tiempo Real de la Polimerasa, Factor Esteroidogénico 1/genética, Factor Esteroidogénico 1/metabolismo

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