LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Rosiglitazone role in the expression of KLF6 caco-2 colon cancer cells

Rojas, Víctor; Laime, Delia.

Int. j. morphol; 35 (1), 2017

Kruppel-like factor 6 (KLF6) is a member of the family of Kruppel transcription factors, this plays an important role in the regulation of cell growth, differentiation and angiogenesis. Rosiglitazone is a PPARy agonist drug, its antitumor effect has been described in models of breast and colon cancer. Th...

Neoplasias del Colon/metabolismo, Tiazolidinedionas/farmacología, Factores de Transcripción de Tipo Kruppel, Adenocarcinoma/metabolismo, Línea Celular, Células CACO-2, Apoptosis, Antineoplásicos/farmacología

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Two novel heterozygous missense variations within the GLI2 gene in two unrelated argentine patients

Two novel heterozygous missense variations within the GLI2 gene in two unrelated Argentine patients

Several heterozygous GLI2 gene mutations have been reported in patients with isolated GH deficiency (IGHD) or multiple pituitary hormone deficiency (MPHD) with or without other malformations. The primary aim of this study was to analyze the presence of GLI2 gene alterations in a cohort of patients with I...