LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effect of the signaling lymphocytic activation molecule (SLAM) in the modulation of T cells in immune response to Leishmania braziliensis in vitro

Coêlho, Zirlane Castelo Branco; Teixeira, Maria Jania; Vilar, Maria do Livramento Leitão; Matos, Jesamar Correia; Coêlho, Ivo Castelo Branco; Andrade, Geanne Matos de; Pompeu, Margarida Maria de Lima.

J. Health Biol. Sci. (Online); 5 (1), 2017

Introduction: Signaling lymphocyte activation molecule (SLAM) is a self-ligand receptor on the surface of activated T- and B-lymphocytes, macrophages, and DC. Studies have shown PBMC from healthy individuals exposed to Leishmania differ in IFN-γ production. Objective: We investigated the role of SLAM si...

Leishmania braziliensis, Familia de Moléculas Señalizadoras de la Activación Linfocitaria, Citocinas, Terapia de Inmunosupresión

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Impaired number and function of lymphocytes in patients with common variable immunodeficiency: a consequence of activation-induced cell death

Introduction: Common variable immunodeficiency (CVID) is an immunological disorder characterized by defective antibody production. Objectives: To study lymphocytes number, surface activation molecules, cell markers, lymphoproliferative response, cytokine production, and cell death. Methods:...