Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
Mem. Inst. Oswaldo Cruz; 113 (10), 2018
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GG...
Análisis de Varianza, Antimaláricos/análisis, Antimaláricos/farmacología, Western Blotting, Resistencia a Medicamentos, Farnesiltransferasa/análisis, Farnesiltransferasa/biosíntesis, Plasmodium falciparum/efectos de los fármacos, Plasmodium falciparum/enzimología, Plasmodium falciparum/crecimiento & desarrollo, Valores de Referencia, Ácido Risedrónico/análisis, Ácido Risedrónico/farmacología