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IMP-1 inhibits renal cell carcinoma 786-O cell growth by targeting EphrinB2 signaling pathway

Liu, Juan; Shi, Hong.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract EphrinB2 plays a critical role in tumor growth. In this study, we studied the antitumor activity of imperatorin derivative IMP-1 in renal cell carcinoma (RCC) by regulating EphrinB2 pathway.. Results showed that IMP-1 inhibited the proliferation of 786-O cells in a dose- and time-dependent manne...
Carcinoma de Células Renales/patología, d0172090, Ciclina D1/efectos adversos, Ciclina E/efectos adversos, d0024530, Fase G1/genética, d0072910, Neoplasias/clasificación
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Neutral space analysis for a Boolean network model of the fission yeast cell cycle network

Ruz, Gonzalo A; Timmermann, Tania; Barrera, Javiera; Goles, Eric.
Biol. Res; 47 (), 2014
BACKGROUND: Interactions between genes and their products give rise to complex circuits known as gene regulatory networks (GRN) that enable cells to process information and respond to external stimuli. Several important processes for life, depend of an accurate and context-specific regulation of gene exp...
Ciclo Celular/fisiología, Quinasas Ciclina-Dependientes/metabolismo, Redes Reguladoras de Genes/fisiología, Schizosaccharomyces/fisiología, Modelos Biológicos, Proteínas de Ciclo Celular/metabolismo, Fase G1/fisiología, Schizosaccharomyces/genética, Biología Computacional, Gráficos por Computador, Simulación por Computador, Redes Neurales de la Computación
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Surgimento de tumores hepáticos e lesöes pré-neoplásicas em fígado de rato com uso de dietilnitrosamina nas fases de síntese e G1 do ciclo celular
Appearance of liver tumors and pre-neoplastic lesions in the liver of rats with the use of diethylnitrosamine in the G1-phase of the cell cycle

Hartmann, Antonio A; Rabes, Hartmut M.
Pesqui. méd. (Porto Alegre); 28 (1), 1994
A proliferaçäo celular é um fator importante para a maior suscetibilidade a transformaçäo maligna da célula. Altas taxas de proliferaçäo de hapatócitos podem ser obtidas através de hepatectomia parcial. Com o uso de hidroxiuréia, uma populaçäo celular em proliferaçäo pode ser bloqueada na ...
Dietilnitrosamina/efectos adversos, Fase S, Fase G1, Hepatectomía, Ratas Wistar