HIGHLIGHTS Sodium arsenite can cause neoplastic transformation in cells. Curcumin reduced cell viability and increased LDH activity in transformed Balb/c 3T3 cells. Curcumin caused DNA damage in transformed Balb/c 3T3 cells. Curcumin may play a protective role in sodium arsenite-induced toxicity....
Abstract: Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient's face, conferring a leonine facies...
Fibroblastos/patología,
Mucinas,
Escleromixedema/clasificación,
Escleromixedema/diagnóstico,
Escleromixedema/patología,
Escleromixedema/terapia,
Piel/patología,
Enfermedades de la Piel/clasificación,
Enfermedades de la Piel/diagnóstico,
Enfermedades de la Piel/patología,
Enfermedades de la Piel/terapia
Abstract Purpose: To evaluate the hyaluronic acid (HA) inflammatory reaction, fibroblasts, fibrosis and duration of effect in the dorsal region of tobacco-exposed rats. Methods: Ten Wistar rats were divided into two groups: tobacco-exposed-group (TEG;n=5) and air-control-group (CG;n=5). The TEG animal...
Modelos Animales de Enfermedad,
Espacio Epidural/efectos de los fármacos,
Espacio Epidural/patología,
Fibroblastos/efectos de los fármacos,
Fibroblastos/patología,
Fibrosis,
Ácido Hialurónico/efectos adversos,
Inflamación/inducido químicamente,
Inflamación/patología,
Exposición por Inhalación/efectos adversos,
Ratas Wistar,
Factores de Tiempo,
Nicotiana/efectos adversos,
Viscosuplementos/efectos adversos
Abstract Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients. Human primary fibroblasts were isolated and cultured to be distributed into 2 groups:...
Araquidonato 12-Lipooxigenasa/análisis,
Araquidonato 12-Lipooxigenasa/efectos de los fármacos,
Ácido Ascórbico/farmacología,
Quemaduras/tratamiento farmacológico,
Quemaduras/patología,
Células Cultivadas,
Estudios Transversales,
Ciclooxigenasa 1/análisis,
Ciclooxigenasa 1/efectos de los fármacos,
Oxidasas Duales/análisis,
Oxidasas Duales/efectos de los fármacos,
Fibroblastos/efectos de los fármacos,
Fibroblastos/patología,
Expresión Génica/efectos de los fármacos,
Glutatión Peroxidasa/análisis,
Glutatión Peroxidasa/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH/análisis,
Valores de Referencia,
Piel/patología,
Peroxirredoxinas/análisis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Estadísticas no Paramétricas,
Ubiquitina-Proteína Ligasas/análisis
Abstract: This study describes a case of a 19-year-old patient with seven asymptomatic lesions on the chest, measuring between 0.5 to 1cm in diameter, with no history of trauma in the region. The immunohistochemical evaluation was positive for vimentin and smooth muscle actin, determining Dermatomyofibro...
Abstract Purpose: To evaluate the efficacy of the application of the human amniotic membrane (HAM) on the inflammatory process, fibroblast proliferation, formation of collagenand reduction of skin wound areas in rats. Methods: Thirty six rats were submitted to a surgical injury induction and divided ...
Amnios/química,
Amnios/trasplante,
Apósitos Biológicos,
Colágeno/farmacología,
Colágeno Tipo I/metabolismo,
Colágeno Tipo I/farmacología,
Colágeno Tipo III/metabolismo,
Colágeno Tipo III/farmacología,
Modelos Animales de Enfermedad,
Fibroblastos/metabolismo,
Fibroblastos/patología,
Inflamación/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Piel/lesiones,
Piel/patología,
Cicatrización de Heridas/efectos de los fármacos,
Cicatrización de Heridas/fisiología
Abstract: Background: Mitochondriopathies are multisystem diseases affecting the oxidative phosphorylation (OXPHOS) system. Skin fibroblasts are a good model for the study of these diseases. Fibroblasts with a complex IV mitochondriopathy were used to determine the molecular mechanism and the main affe...
Abstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a ne...
Alopecia/patología,
Alopecia/fisiopatología,
Deshidroepiandrosterona/fisiología,
Alopecia/etiología,
Alopecia/terapia,
Fibroblastos/patología,
Fibroblastos/fisiología,
Fibrosis,
Liquen Plano/patología,
PPAR gamma/fisiología,
Factor de Crecimiento Transformador beta1/fisiología
Abstract Scleromyxedema or lichen myxedematosus is a rare papular mucinosis of chronic and progressive course and unknown etiology. It is commonly associated with monoclonal gammopathy and may show extracutaneous manifestations, affecting the heart, lung, kidney, and nerves. The diagnosis is based on fou...
ABSTRACT PURPOSE: To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats. METHODS: One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group...
Inductores de la Angiogénesis/uso terapéutico,
Quemaduras/terapia,
Diabetes Mellitus Experimental,
Piel/lesiones,
Terapia por Ultrasonido/métodos,
Cicatrización de Heridas/fisiología,
Quemaduras/patología,
Colágeno/análisis,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/terapia,
Fibroblastos/patología,
Tejido de Granulación,
Modelos Animales,
Necrosis/patología,
Necrosis/rehabilitación,
Ratas Wistar
