LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system

Zakaria, Zainul Amiruddin; Kamsani, Noorsyaza Eddrina; Azizah, Roro; Sulistyorini, Lilis.

Bol. latinoam. Caribe plantas med. aromát; 21 (1), 2022

Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM)...

Melastomataceae/química, Extractos Vegetales/administración & dosificación, Anticarcinógenos/administración & dosificación, Hojas de la Planta, Metanol, Neoplasias del Colon/tratamiento farmacológico, Cromatografía Líquida de Alta Presión, Ratas Sprague-Dawley, Colon/patología, Focos de Criptas Aberrantes, Peso Corporal/efectos de los fármacos, Tamaño de los Órganos/efectos de los fármacos, Antioxidantes, Compuestos Fenólicos, Carcinogénesis/efectos de los fármacos

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Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

ABSTRACT PURPOSE: To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS: Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosi...