Results: 2

Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation

Wang, Dong-Xiao; Huang, Zheng; Li, Qing-Jie; Zhong, Guo-Qiang; He, Yan; Huang, Wei-Qiang; Cao, Xiao-Li; Tu, Rong-Hui; Meng, Jian-Jun.

Acta cir. bras; 35 (1), 2020

Abstract Purpose To investigate whether heat shock protein 90 (HSP90) is involved in complement regulation in ischemic postconditioning (IPC). Methods The left coronary artery of rats underwent 30 min of occlusion, followed by 120 min of reperfusion and treatment with IPC via 3 cycles of 30s reperfus...

Benzoquinonas/farmacología, Proteínas del Sistema Complemento/metabolismo, Forma MB de la Creatina-Quinasa/metabolismo, Proteínas HSP90 de Choque Térmico/antagonistas & inhibidores, Mediadores de Inflamación, Poscondicionamiento Isquémico/métodos, Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo, Lactamas Macrocíclicas/farmacología, Infarto del Miocardio/metabolismo, Daño por Reperfusión Miocárdica/metabolismo, ARN Mensajero/metabolismo, Distribución Aleatoria, Ratas Sprague-Dawley, Factor de Necrosis Tumoral alfa/metabolismo

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Interleukin-6 contributes to myocardial damage in pregnant rats with reduced uterine perfusion pressure

Ding, Lan; Bai, Chuanming; Liu, Ying.

Braz. j. med. biol. res; 51 (8), 2018

Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusi...

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