LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway

Feng, Yubin; Hua, Xiaoxiao; Niu, Ruowen; Du, Yan; Shi, Congjian; Zhou, Renpeng; Chen, Fei-Hu.

Biol. Res; 52 (), 2019

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive and mostly incurable hematological malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently required to improve AML clinical outcomes. 4-Amino-2-trifluoromethyl-phenyl retinate (...

Antineoplásicos/farmacología, Especies Reactivas de Oxígeno/metabolismo, Retinoides/farmacología, Diferenciación Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Supervivencia Celular/efectos de los fármacos, Fosfohidrolasa PTEN/efectos de los fármacos, Fosfohidrolasa PTEN/metabolismo, Fosfatidilinositol 3-Quinasas/metabolismo, Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos, Proteínas Proto-Oncogénicas c-akt/metabolismo, Línea Celular Tumoral, Regulación hacia Abajo, Fluoroinmunoensayo, Leucemia Mieloide Aguda, Transducción de Señal

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Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor...