SUMMARY: This study aims to investigate the effect of Tangzhouling on the morphological changes of Nissl bodies in the dorsal root ganglion of DM Rats. In this study, 69 rats were randomly divided into a control group (n = 10) and a model group (n = 59). The rats in the model group were randomly divided ...
ABSTRACT Objective: To evaluate the lumbar triangular safety zone, its boundaries and its relationship with the dorsal root ganglion through Magnetic Resonance Imaging (MRI). Methods: The boundaries, shape and dimensions of 303 triangular safety zones were analyzed in Tesla 3.0 Magnetic Resonance Imagi...
Farias, V X;
Uchoa, P N;
Aquino, C P;
Britto, L R G;
Fonteles, M C;
Leal-Cardoso, J H;
Silva-Alves, K S;
Havt, A;
Prata, M M G;
Heimark, D B;
Nascimento, N R F;
Santos, C F.
The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8,...
Background and Objective Various irradiances have been reported to be beneficial
for the treatment of neuropathic pain with near infrared light. However, the mechanistic
basis for the beneficial outcomes may vary based on the level of irradiance or
fluence rate used. Using in vivo and in vitro experiment...
Abstract Purpose: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. Methods: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested ...
Conducta Animal,
Western Blotting,
Quimiocina CX3CL1/análisis,
Quimiocina CX3CL1/metabolismo,
Modelos Animales de Enfermedad,
Regulación hacia Abajo,
Ganglios Espinales/metabolismo,
Hiperalgesia/metabolismo,
Desplazamiento del Disco Intervertebral/complicaciones,
Desplazamiento del Disco Intervertebral/metabolismo,
FN-kappa B/análisis,
FN-kappa B/metabolismo,
Neuralgia/etiología,
Neuralgia/metabolismo,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Tiempo
Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by hig...
Secuencia de Bases,
Western Blotting,
Mapeo Cromosómico,
Modelos Animales de Enfermedad,
Ganglios Espinales/lesiones,
Ganglios Espinales/metabolismo,
Ganglios Espinales/fisiopatología,
Regulación de la Expresión Génica,
Datos de Secuencia Molecular,
Neuralgia/metabolismo,
Traumatismos de los Nervios Periféricos/metabolismo,
ARN Largo no Codificante/metabolismo,
ARN Mensajero/genética,
Nervio Ciático/metabolismo,
Transcriptoma
PURPOSE: This aim of this study was to investigate the key genes and pathways involved in the response to pain in goat and sheep by transcriptome sequencing. METHODS: Chronic pain was induced with the injection of the complete Freund's adjuvant (CFA) in sheep and goats. The animals were divided into four...
Dolor Crónico/genética,
Ganglios Espinales/fisiopatología,
Transducción de Señal/genética,
Transcriptoma/genética,
Dolor Crónico/inducido químicamente,
Dolor Crónico/fisiopatología,
Umbral del Dolor/fisiología,
Transducción de Señal/fisiología,
Transcriptoma/fisiología,
Adyuvantes Inmunológicos,
Modelos Animales de Enfermedad,
Adyuvante de Freund,
Perfilación de la Expresión Génica,
Biblioteca de Genes,
Ontología de Genes,
Cabras,
Ovinos
Las inyecciones epidurales de esteroides son frecuentemente indicadas en el sindrome radicular lumbosacro, producido por hernias de disco, protrusiones discales o estenosis del canal, cuando éste no responde al tratamiento no intervencionista. Sin embargo, por distintas causas, aproximadamente 20% de lo...
BACKGROUND: Black widow spider (L. tredecimguttatus) has toxic components not only in the venomous glands, but also in other parts of the body and its eggs. It is biologically important to investigate the molecular basis of the egg toxicity. RESULTS: In the present work, an aqueous extract was prepared f...
Proteínas de Artrópodos/toxicidad,
Araña Viuda Negra/química,
Óvulo/química,
Extractos de Tejidos/química,
Exoesqueleto/química,
Exoesqueleto/fisiología,
Proteínas de Artrópodos/aislamiento & purificación,
Canales de Calcio/efectos de los fármacos,
Cucarachas/efectos de los fármacos,
Ganglios Espinales/efectos de los fármacos,
Óvulo/fisiología,
Nervio Frénico/efectos de los fármacos,
Canales de Potasio con Entrada de Voltaje/efectos de los fármacos,
Extractos de Tejidos/toxicidad,
Canales de Sodio Activados por Voltaje/efectos de los fármacos
Foi feito um estudo combinado a microscopia óptica e eletrônica em embriöes de 10 a 18 dias e em espécimens de 8, 35, 61, e 120 dias após a eclosäo de galo doméstico. O volume nuclear da célula nervosa, praticamente näo varia após o 18ª dia de incubaçäo enquanto que, considerável aumento do...
