LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes

Farias, V X; Uchoa, P N; Aquino, C P; Britto, L R G; Fonteles, M C; Leal-Cardoso, J H; Silva-Alves, K S; Havt, A; Prata, M M G; Heimark, D B; Nascimento, N R F; Santos, C F.

Braz. j. med. biol. res; 52 (6), 2019

The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8,...

Transporte Biológico Activo/fisiología, Western Blotting, Diabetes Mellitus Experimental/metabolismo, Ganglios Espinales/metabolismo, Inositol/metabolismo, ARN Mensajero/metabolismo, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Nervio Ciático/metabolismo, Estreptozocina, Regulación hacia Arriba

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NF-kB mediated CX3CL1 activation in the dorsal root ganglion contributes to the maintenance of neuropathic pain induced in adult male Sprague Dawley rats

Liu, Chenglong; Zhang, Fei; Liu, Haihua; Wei, Fang.

Acta cir. bras; 33 (7), 2018

Abstract Purpose: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. Methods: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested ...

Conducta Animal, Western Blotting, Quimiocina CX3CL1/análisis, Quimiocina CX3CL1/metabolismo, Modelos Animales de Enfermedad, Regulación hacia Abajo, Ganglios Espinales/metabolismo, Hiperalgesia/metabolismo, Desplazamiento del Disco Intervertebral/complicaciones, Desplazamiento del Disco Intervertebral/metabolismo, FN-kappa B/análisis, FN-kappa B/metabolismo, Neuralgia/etiología, Neuralgia/metabolismo, Ratas Sprague-Dawley, Reacción en Cadena en Tiempo Real de la Polimerasa, Factores de Tiempo

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Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury

Mao, P; Li, C R; Zhang, S Z; Zhang, Y; Liu, B T; Fan, B F.

Braz. j. med. biol. res; 51 (10), 2018

Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by hig...

Secuencia de Bases, Western Blotting, Mapeo Cromosómico, Modelos Animales de Enfermedad, Ganglios Espinales/lesiones, Ganglios Espinales/metabolismo, Ganglios Espinales/fisiopatología, Regulación de la Expresión Génica, Datos de Secuencia Molecular, Neuralgia/metabolismo, Traumatismos de los Nervios Periféricos/metabolismo, ARN Largo no Codificante/metabolismo, ARN Mensajero/genética, Nervio Ciático/metabolismo, Transcriptoma

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