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Which Tyrosine Kinase Inhibitor Must We Apply Before? A Case Report of Crizotinib-resistant Patient with Concomitant EGFR and EML4-ALK Gene Mutations

Cokmert, S; Veral, A; Akyurek, N; Kececi, SD; Sivrikoz, O; Yilmaz, E; Tanriverdi, O; Coskun, U.
West Indian med. j; 69 (3), 2021
ABSTRACT The concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocations in lung adenocancers are very rare scenarios. Until now, 42 cases described in the literature have all been treated by different drugs. There is no overall consensus regarding the...
Adenocarcinoma/genética, Neoplasias Pulmonares/genética, Mutación/genética, Genes erbB-1/genética, Exones/genética, Crizotinib/uso terapéutico, Inhibidores de Proteínas Quinasas/uso terapéutico, Docetaxel/uso terapéutico, Cisplatino/uso terapéutico, Antineoplásicos/uso terapéutico, Neoplasias Pulmonares/tratamiento farmacológico, Adenocarcinoma/tratamiento farmacológico
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Molecular profile of non-small cell lung cancer in northeastern Brazil

Oliveira, Ana Claudia da Silva Mendes de; Silva, Antonio Vinicios Alves da; Alves, Marclesson; Cronemberger, Eduardo; Carneiro, Benedito Arruda; Melo, Juliana Carneiro; Martins Neto, Francisco; Tavora, Fabio.
J. bras. pneumol; 45 (3), 2019
ABSTRACT Objective: To investigate the histological subtypes and mutational profiles of non-small cell lung cancer in Brazil, looking for correlations among histological subtypes, expression of anaplastic lymphoma kinase (ALK), EGFR mutation status, and programmed death-ligand 1 (PD-L1) expression. Met...
Adenocarcinoma/genética, Adenocarcinoma/patología, Quinasa de Linfoma Anaplásico/análisis, Antígeno B7-H1/análisis, Biopsia, Brasil, Carcinoma de Pulmón de Células no Pequeñas/genética, Carcinoma de Pulmón de Células no Pequeñas/patología, Genes erbB-1/genética, Inmunohistoquímica, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/patología, Mutación, Valores de Referencia, Estudios Retrospectivos
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Distribution of molecular subtypes of advanced lung adenocarcinoma and clinical outcomes in a center of Argentina

Recondo Jr, Gonzalo; Denninghoff, Valeria; Cuello, María T; Lorente, Constanza; Greco, Martín; De La Vega, Máximo; Recondo, Gonzalo.
Medicina (B.Aires); 78 (6), 2018
The prevalence of relevant oncogenic drivers in lung adenocarcinoma varies in our region and data on clinical outcomes is scarce. The objective of the study was to describe the prevalence of KRAS, BRAF and EGFR mutations and ALK translocations in patients with advanced lung adenocarcinoma, and to depict ...
Adenocarcinoma/genética, Adenocarcinoma/mortalidad, Adenocarcinoma/patología, Quinasa de Linfoma Anaplásico/genética, Argentina/epidemiología, Biopsia, Genes erbB-1/genética, Inmunohistoquímica, Hibridación Fluorescente in Situ, Estimación de Kaplan-Meier, Neoplasias Pulmonares/genética, Neoplasias Pulmonares/mortalidad, Neoplasias Pulmonares/patología, Mutación, Estudios Prospectivos, Proteínas Proto-Oncogénicas B-raf/genética, Estadísticas no Paramétricas
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