LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Poly-ε-caprolactone based nanoparticles for delivery of genistein in melanoma treatment

We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred to as PNTPGS and PNPol, were prepared using nanoprecipitation. They were c...

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway

Bai, Yejun; Li, Zhigang; Liu, Weihao; Gao, Dong; Liu, Min; Zhang, Peiying.

Acta cir. bras; 34 (11), 2019

Abstract Purpose: Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of Trifolium pratense L. This study was intended to explore the effect of BCA on Ml/R injury and explore t...

Antiinflamatorios/farmacología, Aspartato Aminotransferasas/sangre, Western Blotting, Cardiotónicos/farmacología, Creatina Quinasa/sangre, Citocinas/sangre, Genisteína/farmacología, Lactato Deshidrogenasas/sangre, Daño por Reperfusión Miocárdica/metabolismo, Daño por Reperfusión Miocárdica/prevención & control, FN-kappa B/efectos de los fármacos, FN-kappa B/metabolismo, Proteína con Dominio Pirina 3 de la Familia NLR/efectos de los fármacos, Ratas Sprague-Dawley, Valores de Referencia, Reproducibilidad de los Resultados, Transducción de Señal/efectos de los fármacos, Receptor Toll-Like 4/efectos de los fármacos, Receptor Toll-Like 4/metabolismo

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